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Reffsin, Miller, Cherry & Raj et al. discover that intrinsic cell states determine which cells become infected with SARS-CoV-2. Using single-cell clone tracing, they identified a TIG1-high state marking highly susceptible cells. What makes these cells vulnerable? 👇🏻 1/3

20/1/26, 12:50 pm2 reposts5 likes

Adlung Lab

@adlunglab.com

20 Jan

Cells in the TIG1-high state express factors like AXL, TSPAN8, and MUC20 that promote viral entry. Knocking out these genes reduced infection. Importantly, only a subset of ACE2-expressing cells are TIG1-high, explaining why not all permissive cells get infected. How is this relevant? ⤵️ 2/3

Adlung Lab

@adlunglab.com

20 Jan

The TIG1-high state exists in human lung club and ciliated cells, enriched in IPF patients and tobacco users. Different viruses target different states. Influenza A prefers KRT8-high cells. Arjun Raj @cp-cell.bsky.social doi.org/10.1016/j.ce... 🧪 3/3

Unified Equilibrium

@entangledskies.bsky.social

20 Jan

This reads less like a single permissive switch and more like susceptibility occupying a constrained region of cell-state space, which helps explain why ACE2 presence alone is not predictive.