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Intriguing @nature.com paper from @yaleschoolofmed.bsky.social on commensal-derived Acetylcholine, which educates mucosal immunity. Among many other cool things, they monocolonize germ-free mice with more than 100 individual bacterial strains... www.nature.com/articles/s41... 🧪

nature.comCommensal-derived acetylcholine enhances mucosal immune education - NatureA diet–microbiome–host axis strengthens mucosal immune defences and reinforces host–microbiota mutualism.

30/7/26, 8:22 am1 repost5 likes

Adlung Lab

@adlunglab.com

30 July

Also multi-level convergence: Many strains produce Acetylcholine (ACh), from different dietary choline sources. Mice colonized with ACh-producing strains exhibited enhanced intestinal immunoglobulin A production, altered microbiota composition and increased resistance to enteric infection.