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Please check our collaborative paper with Marcin Suskiewicz and Sebastien Huet labs on FAM118 proteins – non-canonical sirtuins that form filaments and act as NADases in human and other vertebrate cells. www.nature.com/articles/s41...
nature.comFilament formation and NAD processing by noncanonical human FAM118 sirtuins - Nature Structural & Molecular BiologyBaretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that FAM118A/B processing of NAD involves head-to-tail filament...
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