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Check out the first tool from Bind Research: SpinForecast. #NMR is one of the most powerful tools for probing the atomic behaviour of IDPs. But the data can look like a Jackson Pollock painting: a sea of peaks that we must painstakingly match to positions along the protein backbone.

This Sudoku-like puzzle is called assignment, and for gnarly IDPs, it can take weeks to solve. Our recent work combines data from the BMRB with predictions from AlphaFold2 to generate probabilistic assignments for IDPs, streamlining this process.

We tested SpinForecast against independently determined assignments for IDPs of increasing size and complexity. Across fully disordered proteins, it assigned approximately 40–75% of signals with 100% confidence, and those assignments were more than 99% accurate. #NMRchat #NMR #ChemSky

For the remaining signals, it returned a ranked shortlist of likely candidates, with the correct residue appearing on that shortlist more than 97% of the time.

New to #NMR? Our blog post explains the science behind SpinForecast and why assignment matters: bindresearch.org/news/solving... #NMRchat #ChemSky

Fellow disordered protein 🍝 and NMR nerds 🧲: check out the preprint: www.biorxiv.org/content/10.6...