Rémi Buisson on Mythryl: “Great collaboration with Tim Fonton's team, which uncovered a new…”

@buissonlab.bsky.social

Great collaboration with Tim Fonton's team, which uncovered a new role for APOBEC3A during keratinocyte differentiation. @TimFenton10 showed that aberrant activation of GRHL3 in dividing cells could potentially drive mutagenic APOBEC3A activity in cancer. www.embopress.org/doi/full/10....

embopress.orgDifferentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma | The EMBO JournalimageimageAPOBEC3A and APOBEC3B encode DNA editing enzymes with anti-viral roles that generate somatic mutations in cancer. This study provides insight into their expression in healthy and cancerous e...

15/11/24, 5:29 pm0 reposts6 likes

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