Post

Bussi Lab
@bussilab.org

New #preprint alert! 🧬 MERGE-RNA: a physics-based model to predict #RNA secondary structure ensembles with chemical probing, lead by Giuseppe Sacco, in collaboration with Guido Sanguinetti and Redmond Smyth's lab arxiv.org/abs/2512.20581

arxiv.orgMERGE-RNA: a physics-based model to predict RNA secondary structure ensembles with chemical probingThe function of RNA molecules is deeply related to their secondary structure, which determines which nucleobases are accessible for pairing. Most RNA molecules however function through dynamic and het...
Bussi Lab
@bussilab.org

We develop a method to reconstruct RNA 2D ensembles based on nano-DMS-MaP data! Correlation as not measured from data, but rather inferred via a physics based model, which describes also RNA-probe interaction and can be straightforwardly extended to multiple reagents

0 reposts0 likes