Communications Biology on Mythryl: “ESR1-mutant #breastcancers show increased mutational burden…”

@commsbio.nature.com

ESR1-mutant #breastcancers show increased mutational burden, proliferation, and enhanced mTORC1 signaling, linking ER activity to tumor aggressiveness. A multi-omic signature predicts #ESR1 mutations and identifies patients at higher risk of recurrence and poor outcomes. doi.org/10.1038/s420...

doi.orgESR1 mutations are associated with enhanced MTORC1 signaling in a context-dependent manner - Communications BiologyESR1-mutant breast cancers show increased mutational burden, proliferation, and enhanced mTORC1 signaling, linking ER activity to tumor aggressiveness. A multi-omic signature predicts ESR1 mutations a...

8/10/26, 2:39 pm1 repost2 likes

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