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i think the biggest and clearest area i have seen in my personal life has been multiple sclerosis meds - we've taken it from something that's basically guaranteed to land you in a wheelchair to something that's mostly fine as long as you have an insurance willing to pay $10k/mo for the good stuff

Insulin pumps have gone from devices that need to be kept in a bag or fanny pack type case to a small plastic patch you can just stick on your arm that communicates with a constant glucose monitor to algorithmically deliver insulin automatically