Association of orphan nuclear receptors and heterochromatin are involved in Alternative Lengthening of Telomeres – Liuh-Yow Chen and coworkers identify their link as the transcriptional corepressor TRIM28 Thanks to @reviewcommons.org for another #RefereedPreprint link.springer.com/article/10.1...
link.springer.comOrphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the ALT pathway - The EMBO JournalAlternative lengthening of telomeres (ALT) is a telomere maintenance mechanism deployed in embryonic stem cells and cancer cells. High levels of the heterochromatin mark H3 lysine 9 trimethylation (H3...
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