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Faithful #mitosis depends on precise regulation of #separase. Learn how Sak1/LKB1 activates separase and promotes its nuclear localization. Vaquero-Pelaz, Queralt et al. reveal a novel regulatory mechanism conserved from yeast to humans. rupress.org/jcb/article/... #CellCycle #CellBiology

20/10/26, 5:00 pm2 reposts2 likes

Journal of Cell Biology

@jcb.org

See a short video summary by the first author, David Vaquero-Pelaz: youtu.be/H8zA2iFOvMA

youtu.beThe AMPK kinase Sak1 activates separase and promotes its nuclear localization during mitosisOriginal paper: https://rupress.org/jcb/article/225/11/e202505056/283093/The-AMPK-kinase-Sak1-activates-separase-and Video summary by David Vaquero Pelaz (Instituto de Biomedicina de Valencia,…