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New work from Mayca Pozo et al. @septinlab.bsky.social reshapes #septin biology: septins relieve #actomyosin forces, shielding #actin & the #nucleus from mechanical damage. SEPT9 overexpression may promote tumor cell survival by limiting genomic damage during #metastasis. rupress.org/jcb/article/...

22/10/26, 4:31 pm3 reposts10 likes

Journal of Cell Biology

@jcb.org

See the related study from @maggieutgaard.bsky.social, @myosincity.bsky.social, @pwoakes.bsky.social et al. rupress.org/jcb/article/...

rupress.orgMechanically induced septin networks protect nuclear integrityUtgaard et al. show that septins accumulate at the cortex in response to mechanical cues, where they serve to buffer mechanical forces that act on the nucl