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1) 🇺🇸 A new paper in Nature shows that viral reactivation is common in COVID-19, associated with severity and not primarily a consequence of immunosuppression. The association with Long Covid, however, was far from clear.

3) Samples were collected multiple times so we can see a trajectory of viral reactivation. EBV reactivation, for example, started high but quickly declined, whereas Anelloviridae reactivation showed a slower decline.

4) The measurements were taken prior to the definition of Long Covid, but the study does include patient-reported outcomes (PROs) from which they made 4 LC subgroups.

5) The paper notes, however: "Upon evaluating viral reactivation during the acute stage of COVID19, no significant relationship was found with PRO groups." So there was no link between viral reactivation during acute infection and Long Covid.