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2) I suspect the media attention is mostly driven by commercial interests, rather than the significance of the scientific findings. The paper comes from the company Oxford BioDynamics (OBD) that developed a new test called EpiSwitch which they applied to ME/CFS.

3) Their previous paper used 200 parameters (based on 3D folding of chromosomes) but they tested it in small samples of less than 100 ME/CFS patients. The controls were not properly matched for age, sex and other factors. That paper already raised some eyebrows...

4) In this new study, they compare results for ME/CFS to other fatiguing diseases such as MS, rheumatoid arthritis, PTSD and Long Covid. They report various connections but there's no clear null model to test if these or more than what one would expect based on chance alone.