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1/3: We are proud to share that the recent work by postdocs Karen Palacio-Rodriguez and Sergio Cruz-León, from Gerhard Hummer’s department, was selected as one of the Editors’ Highlights in Nature Communications! 🎉 👏 Open-access paper: 👉 www.nature.com/articles/s41...

Max Planck Institute of Biophysics

@mpibp.bsky.social

19 June

2/3: Using high-resolution cryo-EM 🔬 (in collab with Fabio Lapenta) combined with multi-scale molecular dynamics simulations 🧬, the team resolved two distinct conformational states of the human vault particle.

Max Planck Institute of Biophysics

@mpibp.bsky.social

3/3: This revealed the structural mechanisms behind its characteristic “breathing” motions. Simulation-guided mutagenesis reveled key contacts for the the particle's stability, opening new doors for the rational engineering of vaults as nanoscale delivery systems. 👉 www.nature.com/articles/s41...

nature.comStructural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations - Nature CommunicationsVaults are widespread, large cellular particles with unknown function. Here, the authors reveal how vaults flex and change shape using imaging and simulations, identifying key interactions that contro...

19/6/26, 1:15 pm0 reposts5 likes

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