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Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure. We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)

🐁 Stop guessing your model organism. Our new search engine allows you to rank model organisms by their structural fidelity to specific human pathways. Case Study: For Fanconi Anaemia, Mouse is perfect. Yeast fails. C. elegans is a hidden gem. (2/5)

⚙️ A Bipartite Evolutionary Mode The eukaryotic proteome isn't a uniform soup. We resolve it into two distinct modes: A rigid "Architectural Core" (Cytoskeleton/Chaperones) A highly plastic "Operational Engine" (Metabolism/Translation) (3/5)

🕊️ Structural Acceleration Does a bigger genome mean faster structural evolution? No. We found lineage-specific bursts of structural innovation in Birds (Aves) and Ants (Hymenoptera) that are distinct from genomic expansion. (4/5)