Science Magazine on Mythryl: “A two-step mechanism may shape how Wnt ligands induce different…”

A two-step mechanism may shape how Wnt ligands induce different responses in cells depending on which coreceptor interacts with the receptor Frizzled—a discovery that may inform research into selective modulators of the Wnt pathway. #ScienceSignaling https://scim.ag/4mf3CwN

scim.agWnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for β-catenin stabilizationFzd clustering is sufficient for Wnt-induced phosphorylation of Dvl but not for activation of β-catenin.

8/4/26, 3:00 pm3 reposts17 likes

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