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💊 The Pain Paradox: Activating TRPV1 to Silence Its Response - Researchers leveraged rational drug design, functional experiments, and #cryoEM to characterize a new capsaicin-inspired TRPV1 agonist with prolonged analgesic effects. Read more in the #CryoSPARC Blog 👉 cryosparc.com/blog/trpv1-m...

Structura Biotechnology

@structurabio.bsky.social

1 Sept

TRPV1 helps sensory neurons detect potentially harmful stimuli, but activation is only part of the story: prolonged stimulation can also drive the channel toward desensitization, reducing its responsiveness.

Structura Biotechnology

@structurabio.bsky.social

The MSP20-bound TRPV1 #cryo-EM structure solved in this paper adds an important molecular perspective to the functional observations, helping connect how the compound binds to TRPV1 with how the channel responds over time.

1/9/26, 12:01 pm0 reposts0 likes

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