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@triggerloop.bsky.social

Three @biorxivpreprint.bsky.social preprints on acute depletion of FACT in ES cells. First, from my colleague at Pitt Sarah Hainer's lab 1/ www.biorxiv.org/content/10.6...

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27/2/26, 8:44 pm7 reposts18 likes

@triggerloop.bsky.social

Second, from Thomas Milne's group 2/ www.biorxiv.org/content/10.6...

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@triggerloop.bsky.social

Third, from Anja Groth's lab 3/ www.biorxiv.org/content/10.6...

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@triggerloop.bsky.social

These preprints each have different types of experiments but they show strong effects on nucleosomes adjacent to promoters along with apparent spreading of TFs into genes where nucleosomes are lost/disrupted. Two of the papers look at consequences for 3D genome organization. 4/4

@mcduncanlab.bsky.social

I initially thought this string of posts about fact depletion was political.

Manny Ares 👀

@mannyares.bsky.social

we're in the post-FACT era

@mcduncanlab.bsky.social

Not for long if you read the papers.

@triggerloop.bsky.social

💅