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Olga Anczukow@olgaanczukow.bsky.social

Lung tumors mis-splice STAT2, a key immune gene, building a broken form that actively jams the signal rather than staying quiet. That splicing glitch associates with immunotherapy response. 🧵 #RNAbiology #RNAsky #RNAsplicing #cancer #immunotherapy @jax.org www.science.org/doi/10.1126/...

science.orgIntron retention regulates STAT2 function and associates with immunotherapy response in lung cancerImmunotherapy with checkpoint inhibitors has revolutionized cancer therapy and enabled considerable therapeutic advances for treating various diseases, including lung cancer. However, the molecular de...