William DeWitt on Mythryl: “I'm stoked to have this long-term and highly collaborative effort…”

@wsdewitt.github.io

I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.

Gabriel Victora@victora.bsky.social

Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...

biorxiv.orgReplaying germinal center evolution on a quantified affinity landscapeDarwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...

7/6/25, 11:30 pm14 reposts39 likes

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