Otto Balsiger

Organoid co-culture and organ-on-chip systems are transforming how we study immune–epithelial interactions, enabling more precise, patient-relevant models of disease 🧬 🔗 vist.ly/5py28 #Immunology #Organoids #Microfluidics #PrecisionMedicine

🚀 Building on years of CAR‑T and TCR‑T innovation, this study showcases a sophisticated “all‑in‑one” engineered T‑cell approach for AML, combining antigen specificity, microenvironment responsiveness, bystander recruitment, and a safety switch in a single vector. Read more: vist.ly/5py27

Submissions are still open for our CD40 turns 40 Special Collection, exploring four decades of CD40 biology and its impact on immunotherapy across cancer, autoimmunity, and more 🧬 Learn more about submitting here: vist.ly/5pmz9 #Immunology #Immunotherapy

Chickenpox and shingles are caused by the same virus. After chickenpox, it can reactivate years later as shingles. The shingles vaccine prevented an estimated 40,500 GP consultations and 1,840 hospitalisations in its first five years in England. ➡️ vist.ly/5pyi9

Enhance your omics data skills with our hands-on bioinformatics training, tailored for wet-lab scientists with limited experience in R. Join over 3,000 attendees who rated us 9.5/10! Secure your spot for 7–18 Dec (mornings 09:30–12:30) 2026: vist.ly/5pg4c

Leiden University researchers studied 79 Long COVID patients and found elevated complement regulators Factor H and C4BP. In severe COVID, patient serum also made blood vessel cells more vulnerable to complement attack. academic.oup.com/cei/advance-...

A simpler, highly specific way to detect AIH? This study shows that MF-SMA patterns on vascular smooth muscle cells are easy to recognize and match gold-standard specificity, offering a more reliable diagnostic approach. 🧬 vist.ly/5pb72 #Immunology #Autoimmunity #LiverDisease

Early splenectomy delays inflammation and reduces joint damage in a mouse model of autoimmune arthritis, highlighting a surprising protective role when done at early stages. 🧬 vist.ly/5pb5v #Immunology #Autoimmunity #Arthritis

New research in Immunotherapy Advances suggests age related differences in how children and adults process immunoglobulin replacement therapy are unlikely to be clinically meaningful. The findings support dosing guided by individual needs, rather than age alone. Read more: vist.ly/5pgfc

This review explores the bottom-up development of LGR5-targeting immunotherapeutics, showing how a highly specific α‑LGR5 antibody can be adapted into multiple modalities 📖 Read more: vist.ly/5pb85 #Immunotherapy #CancerResearch #CARTcells #PrecisionMedicine #OpenAccess

Today is the #BSI26 early bird deadline! Booking now could save you up to £90, depending on your registration category. It's also the last day to submit a poster presentation. Register and submit here: vist.ly/5pat6

T cell activation depends on rapid gene expression changes. This study shows RAM is upregulated during activation and is essential for RNA cap formation, driving protein synthesis and CD4 T cell proliferation. 🔗 vist.ly/5nyx3 #Immunology #TCells

What connects cancer immunotherapy, metabolism and ageing, and the neuroimmune axis? Explore the science and speakers to look forward to at #BSI26 in Glasgow: vist.ly/5p5fw 📅 Early bird and late breaking abstract submissions close tomorrow!

We're at #Cytokines2026 in Glasgow! Our team is here showcasing the BSI's journals portfolio and what we offer the immunology community. Come and visit our stand to find out more, pick up some goodies and say hello 👋

The NIH is proposing changes to their Biosafety Policy for Research Involving Biohazards, including updating to techniques defined as 'genetic modification'. We encourage our members to share their perspectives on the proposed changes here: vist.ly/5nyk2

Learn bioinformatics wherever you are! Our self-paced courses let you learn at your own pace, with ongoing support from the Glasgow Bioinformatics Core, “This is probably the most useful course I have ever attended” Member discounts! Explore the courses: vist.ly/5nywz

Tracking engineered T cells after infusion is crucial. This study shows a rapid whole-blood assay can assess TCR T cell function in vivo, with cytokine responses reflecting dose in HBV-related liver cancer. 🔗 vist.ly/5nyxv #Immunotherapy #TCells #Immunology

Are you working at the intersection of immunology and ecology? We’d love to hear from you! Join us in exploring how ecological factors shape immune responses in wild animals and humans. 🔬🌳 Find out more and submit: vist.ly/5nyy3

BSI Congress is about more than what happens on stage. It’s the conversations between sessions, questions after talks, poster discussions and catching up with colleagues from across the field. Join us in Glasgow for #BSI26. Early bird closes in 2 days: vist.ly/5nyfd

🧬 How does ageing with frailty reshape immune responses? This open‑access study links altered neutrophil signalling to impaired chemotaxis and increased ROS/NET production, highlighting key features of inflammageing. 👉 vist.ly/5nnmh #ImmuneAgeing26

γδ T cells in the female reproductive tract, quiet defenders or active players in pregnancy? 🤔 This review unpacks their dynamic, hormone-responsive roles at this unique barrier site ⚖️ Part of our T Cells at Barrier Sites collection🧬 vist.ly/5nnmd

🔬 Regulatory B cells are key to immune balance, but their role in autoimmune disease is highly variable. This highlights the need for more personalised approaches to treatment. 📖 vist.ly/5nnm2

Population modelling reveals key drivers of CAR T-cell dynamics in lymphoma patients, highlighting roles for lymphodepletion, tumour burden, and cytokines like IL-15/IL-7 🧬 🔗 vist.ly/5nbu9 #Immunotherapy #CARTcells #CancerResearch

Abatacept suppresses T cell activation, but how durable is its effect? Research shows its inhibitory impact is short-lived in vivo, diminishing significantly once treatment stops 🧬 🔗 vist.ly/5nbtu #Immunology #Tcells #Autoimmunity

This review explores how long non-coding RNAs influence oral squamous cell carcinoma . The article brings together emerging evidence on the nerve–immune–cancer axis and highlights future directions for identifying new biomarkers and therapeutic targets. 📖 vist.ly/5n69b #Immunology

This open‑access study shows the β‑blocker nebivolol prevents T‑cell exhaustion and boosts cytotoxicity against breast cancer cells via β₂‑adrenergic receptor–dependent signalling, highlighting a potential new immunomodulatory strategy. vist.ly/5nbt2

Attending #ESID2026 this week? Come and say hello to us at booth 23b to find out about becoming a BSI member, explore our training and professional development opportunities and see why our journals are a perfect home for your research.

Meet our #BSI26 keynote speaker, Prof Adrian Hayday! His pioneering research on gamma delta (γδ) T cells has transformed our understanding of their role in cancer, inflammation and tissue immunity. Early bird registration closes 21 October: vist.ly/5myvt

📢 New in Discovery Immunology New open-access research shows a strikingly shared (“public”) antibody response following PRV vaccination and challenge, revealed through porcine BCR repertoire profiling 🧬 🔗 vist.ly/5mz8c #Immunology #Vaccines #Bcells #OpenAccess

Pathogenic CD4⁺ T cells in experimental uveitis share key features with those seen across immune-mediated inflammatory diseases, highlighting common pathways driving chronic inflammation 🧬 🔗 vist.ly/5mz98 #Immunology #Autoimmunity #Tcells

A high-affinity ImmTAC® bispecific efficiently redirects T cells to target PRAME+ tumour cells, even at very low antigen levels, highlighting its promise across multiple cancers 🧬 🔗 vist.ly/5mz8r #Immunotherapy #CancerResearch #Tcells #OpenAccess

What was once one of the most feared infectious diseases is now extremely rare in the UK. Our #CelebrateVaccines blog explores the history of polio, from devastating epidemics to the development of vaccines that changed the course of the disease. 🔗 vist.ly/5myr4

It’s a great time to get a flu vaccine! 💉

A simple whole-blood assay enables rapid, in vivo monitoring of engineered TCR T cell function, capturing cytokine responses post-transfer without complex processing. A practical step for tracking cell therapy performance. 🧬 vist.ly/5mnx8 #Immunotherapy #Tcells #CellTherapy

RNA capping emerges as a key checkpoint in T cell activation: RAM upregulation is essential for RNA cap formation, gene expression, and proliferation, linking transcriptional control to immune function. 🧬 vist.ly/5mnxg #Immunology #Tcells #GeneExpression

There’ll be a lot to explore at #BSI26! From immunometabolism and cancer immunotherapy to infection, inflammation, neuroimmunology and clinical immunology, this year’s programme spans the breadth of the field. Join us in Glasgow and save by booking by 21 Oct: vist.ly/5mc9i

⏳Just one week to go until #ESID2026! Don't forget, we'll be exhibiting at the event and would love to connect with the #PID and #IEI communities. If you're looking for a home for your research or would like to set up a meeting, please get in touch!

Check out this Editorial from @pallettlab.bsky.social and @schurichlab.bsky.social introducing our new section and the exciting research area that is #immunometabolism Read it here 🖱️ vist.ly/5m4ek

Single-cell insights reveal how “periodic” TCR signalling shapes self-reactive T cells, and how HTLV-1 exploits this pathway. A fresh model with implications for cancer and immunotherapy. 🧬 Read here: vist.ly/5mcnr #Immunology #Tcells #HTLV1

A step forward in evolving cell therapies for AML: integrating TCR, CAR, BiTE, and safety switch into a single engineered T cell highlights how the field is moving toward multi-functional, adaptable designs to overcome tumor complexity. vist.ly/5mcnu #Immunotherapy #AML #CellTherapy

Want to get started with R and omics data analysis? Our top-rated beginner course runs over 10 mornings on Zoom (7–18 Dec, 09:30–12:30), covering R, omics data analysis and practical data visualisation. BSI members: £350 + VAT (50% off)! Find out more: vist.ly/5mhbx

70 years of the BSI! We're so excited to bring the immunology community together in Glasgow to celebrate 🥳 Join us for #BSI26 from 30 Nov to 3 Dec, with 1,500+ delegates and 4 days of immunology research, clinical insights and networking. Early bird closes 21 October: vist.ly/5keek

📢 New open‑access study shows MAGE‑A4‑specific TCR‑NK cells combine innate NK killing with targeted TCR activity ,offering a potent, safe, “off‑the‑shelf” strategy for solid tumors. 🔗 vist.ly/5k2iy

🧬 Open‑access study highlights ILC3 as key players in endometrial repair and regeneration, with distinct subsets active during menstruation and tissue rebuilding. Changes in ILC3 positioning in endometriosis may disrupt this process. 👉 vist.ly/5k2ic #Immunology #ILC3 #EndometrialHealth

📢 New open‑access study reveals that people with type 2 diabetes accumulate senescent‑like CD4+ EMRA T cells, driven by high glucose and mitochondrial dysfunction, helping explain weaker COVID‑19 vaccine responses in T2D. 🔗 vist.ly/5k2ja

Could a high-fat diet help to protect against colitis in #Chron’sDisease? 🐁 High-fat diet inhibited the development of DSS-induced #colitis in mice, suggesting this diet influences gut barrier integrity and bacterial colonisation of the gut, reducing inflammation. 🔗 vist.ly/5kqzb

🧬 Open‑access research reveals that CASPASE‑8 supports αβ T‑cell survival through mechanisms independent of RIPK1‑mediated necroptosis, with key roles in CD8 T‑cell maintenance and NKT cell development. 👉 vist.ly/5kqxj #Immunology #TCells #CellDeath #OpenAccess

📢 New open‑access pediatric PID study published: fSCIG 10% maintains stable IgG levels in children aged 2–<16 years, with consistent pharmacokinetics across age groups and support for every‑3–4‑week dosing, helping reduce treatment burden without compromising efficacy. 🔗 vist.ly/5kqy3

Today, on International Day of Older Persons, we're launching a new BSI and CARINA Network report on immune health and healthy ageing. It sets out recommendations to better integrate immune health into UK policy, research & healthcare. Read the report: vist.ly/5kjgv