Mr Wickham

Mr Wickham

@wickham.bsky.social

57 followers17 following10 posts

Mr Wickham reposted

Mr Wickham reposted

Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again. #Pinks #ProudBlue

Mr Wickham reposted

Mr Wickham reposted

A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes

Mr Wickham reposted

Congratulations @kezlane.bsky.social and @alison-harrod.bsky.social and thanks to all our fabulous collaborators!

Karen Lane@kezlane.bsky.social

Delighted to share that our paper on the role of PBAF in centromere integrity is out now in @natcomms.bsky.social! It was a long journey but it was made so much easier thanks to my co-first author/coding whiz @alison-harrod.bsky.social, the whole @thedownslab.bsky.social team, & our wonderful boss!

Mr Wickham reposted

These are two awesome, talented postdocs! Lucky to have them in the lab 😍

Alison Harrod@alison-harrod.bsky.social

Cheers @kezlane.bsky.social to our co-first author paper on PBRM1 and the centromere being published this week in @naturecomms.bsky.social! @thedownslab.bsky.social @icr.ac.uk

Mr Wickham reposted

If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...

nature.comPBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature CommunicationsCentromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...

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