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By theme adding think things like weird west (western + horror + scifi) or Cyberpunk Noir (detective + scifi + dystopian)

Oh, I thought you meant themes such as “the individual versus the group”, “can evil ever be redeemed?”, or “hope overcomes all”. I’d call your list genres and/or tropes, and I think it’s probably fine to combine any number if they are properly syncretised and not just thrown together.

I was debating what term to use, but I generally feel board gamers use theme in the same way genre is used in literature. If I asked what theme is Western Legends, I feel like people would say western not individualism. Maybe themes has different connotations to theme? Language is weird sometimes