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🧵 My former office mate and esteemed colleague Anna Huhn has co-authored a groundbreaking study in @naturecomms.bsky.social. 🦠 We're talking viruses and antibodies! 1/5

🧮 Supervised by Omer Dushek (with the fantastic handle @tcell.bsky.social), they've tackled a longstanding immunology question: ⍰ Why does viral neutralization by antibodies sometimes fail to correlate with their antigen-binding affinity? 2/5

🔄 Using a mathematical model & experiments, they showed that antibodies with greater molecular reach are significantly more effective in neutralizing SARS-CoV-2, even when binding affinity is identical. 📍 This discovery underscores the importance of spatial dynamics in antibody function. 4/5

🔗 Dive into this fascinating work here: doi.org/10.1038/s414... . 🏁 Kudos to Anna Huhn et al. for this remarkable contribution to basic immunology! 🧪 5/5