TRAstonDrs

@jonathanrydermd.bsky.social

6 Dec 2024

Our greatest strength lies in the gentleness and tenderness of our heart. Rumi

TRAstonDrs reposted

Jonathan Ryder, MD

26m

New CDC Antimicrobial Resistance Threats report released today Any surprises? I was glad they are monitoring clinda & other drug resistance in GAS arpsp.cdc.gov/artr/antimic...

#Medsky🧪 #cardiosky🫀 #publichealth #krebcycle & the heart matter This review examines how amino acids extend beyond protein synthesis to influence cardiac energy balance, signalling pathways and #CVD development bpspubs.onlinelibrary.wiley.com/doi/full/10....

while supplementation strategies show cardioprotective benefits. 🫀Other Amino Acids: The paper also covers the roles of asparagine, glycine, tryptophan, alanine, and sulphur-containing amino acids,

highlighting how their metabolic pathways and targeted supplementation or dietary restrictions influence atherosclerosis, hypertension, and cardiac remodeling.

🫀BCAAs :Dysregulation of BCAA homeostasis is heavily implicated in #CVD pathogenesis, including insulin resistance, hypertension, and myocardial injury. Therapeutic approaches targeting BCAA catabolism (such as BCKDK inhibitors like BT2 and certain angiotensin II receptor blockers)

show potential in improving cardiac function. 🫀Glutamate and Glutamine: Glutamine acts as a major carbon source for the TCA (Kreb cycle) through glutaminolysis. Alterations in glutamine and glutamate levels are linked to oxidative stress, inflammation, and heart failure,

Additionally, high BCAAs prevent the uptake of tryptophan and tyrosine in the brain, decreasing the synthesis of serotonin (5-HT) and catecholamines to negatively affect central blood pressure regulation. The intricate relationship between amino acid metabolism and CVDs.

🔁 Metabolic Shifts: While amino acids are primarily used for protein synthesis in healthy hearts, they play crucial roles in ATP generation, anaplerosis (replenishing TCA cycle intermediates), and cellular signaling under pathological conditions like heart failure and ischemia.

and further exacerbates insuli 🫀 #Cardiomyocyte Injury and Pyroptosis: Accumulation of BCAAs heightens both acute and chronic myocardial injury, deteriorates cardiac function, and activates pyroptosis in cardiomyocytes via NLRP3/ASC/Caspase-1 signaling pathways.

🫀Mechanisms in Hypertension: Elevated BCAAs can increase the risk of developing hypertension. For instance, leucine has been shown to inhibit nitric oxide (NO) synthesis from L-arginine, while high circulating BCAAs can increase vascular resistance independently of NO signaling.

disrupt insulin-mediated phosphorylation of Akt/protein kinase B (AKT). This decreases insulin-stimulated glucose uptake and alters insulin signaling, leading to insulin resistance, which is closely linked to cardiovascular dysfunction.

🫀mTORC1 Overactivation: Leucine, a specific BCAA, can directly bind to sestrin2 (a negative regulator of mTORC1). Elevated BCAA levels lead to overactivation of the mammalian target of rapamycin complex 1 (mTORC1), which modulates cardiac hypertrophy, cardiac remodeling,

Journal of Experimental Medicine

Dysregulation of BCAA homeostasis contributes to 🫀 pathology, including #heartfailure and #hypertension, through several specific mechanisms: 🫀 Insulin Resistance and Signaling Interference: High levels of circulating extracellular BCAAs

TRAstonDrs reposted

@jem.org

23h

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. From Emily Siniscalco, Courtney Fisher, Meng-Ping Lu, Stephanie Eisenbarth, Uthaman Gowthaman and colleagues: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

Even in the midst of life’s many storms We have the capacity to stand in the centre of our own peace. Project Happiness (Randy Taran), ref Marcus Aurelius's concept of an "inner citadel"

It feels as if I were losing all light. The evening draws near and secretly the house grows dim; I stretch out both arms in solitude, and no one tells me where I belong. Rainer Maria Rilke from: 🌹To Celebrate You* 1897/98

#Medsky🧪 #vaccinesmatter #publichealth #episky #Hypertension is a key, adjustable factor behind major #CVD including #coronaryheartdisease and stroke so early detection is crucial, #LongCOVID was independently associated with a significantly increased risk of new-onset hypertension

For those who experiencing multiple #COVID reinfections significantly increases the risk of developing LC and new-onset #hypertension, whereas receiving #COVID19 💉 provides strong protection against these long-term cardiovascular conditions @nature.com www.nature.com/articles/s41...

evidence.nihr.ac.ukVaccines and long COVID: Do they reduce the risk?Research found that people who had vaccines for COVID-19 had a lower risk of long COVID. This provides support for the benefits of vaccines.

evidence.nihr.ac.uk/alert/vaccin... www.sciencedirect.com/science/arti... www.gavi.org/vaccineswork... 🔥Avoiding reinfections through up-to-date boosters is a primary medical recommendation to protect long-term cardiovascular health

@ahajournals.bsky.social www.ahajournals.org/doi/10.1161/... portal.research.lu.se/en/publicati... www.ovid.com/journals/aje...

individuals with physician-diagnosed LC have a 14% higher risk of developing incident #hypertension (high BP) than those who did not develop LC. the study highlights that this elevated risk persists even among individuals whose initial #COVID infection was mild and did not require hospitalisation

theconversation.comHow El Niño could push up your mortgage and grocery billsA Pacific climate event has far reaching effects.

#Medsky🧪 #publichealth Weather or not How El Niño could push up your mortgage and grocery bills @uk.theconversation.com theconversation.com/how-el-nino-...

TRAstonDrs reposted

Richard Sever

@richardsever.bsky.social

"A single mutation could...spark a pandemic...deadlier than COVID-19...Instead of trying to stop the outbreak and prevent it from spilling into humans...officials have done little except try to keep its existence quiet" www.propublica.org/article/bird...

propublica.orgBird Flu Is Raging on a Mink Farm. It Could Spark a Human Pandemic, Experts Say, but Officials Won’t Act.Federal officials brushed off the issue as Utah prioritized the fur industry’s interests. Little has been done to stop the spread of the virus and ensure it can’t spread to humans, a failure that expe...

TRAstonDrs reposted

Eric Levi

@drericlevi.bsky.social

Your voice matters. There’s an explosion of science and experience in this space. #ENT #Surgeons and #Speech Pathologists are available to help with your airway, voice and swallowing concerns.