Post

We have another preprint to share, this time looking at molecular and functional correlates of opioid use disorder (OUD) in the human DRG 📝 #PainResearch www.biorxiv.org/content/10.6...

biorxiv.orgbiorxiv.org

Dr. Ali Barry

@aliibarry.com

Sensory ganglia recovered from organ donors with OUD showed disrupted glial & immune signalling across omics, with electrophysiology suggesting the nociceptors from these donors are functionally sensitized 🧬🔬

17/10/26, 1:56 pm0 reposts0 likes

Dr. Ali Barry

@aliibarry.com

Opioid withdrawal is known to be painful, and documented reports of "joint pain" and "rheumatism" during withdrawal date back ~500 years. We speculate that a peripheral inflammatory state contributes to this.

Dr. Ali Barry

@aliibarry.com

Previous work has also show changes in neuroimmune signalling in the CNS of mice and humans with chronic opioid use... we are extending this to the human PNS

Dr. Ali Barry

@aliibarry.com

Also, unlike mice, human SGCs express OPRK1. This has been reported before by the Iadarola Lab, which we were able to validate across a few different methods. It probably matters.

Dr. Ali Barry

@aliibarry.com

This work would not have been possible without our NIH funding or the STA & our incredible team of surgeons. From our organ donors & families to everyone who contributed stories of dependency and withdrawal through published research interviews and written personal accounts - thank you.