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We have another preprint to share, this time looking at molecular and functional correlates of opioid use disorder (OUD) in the human DRG 📝 #PainResearch www.biorxiv.org/content/10.6...

Sensory ganglia recovered from organ donors with OUD showed disrupted glial & immune signalling across omics, with electrophysiology suggesting the nociceptors from these donors are functionally sensitized 🧬🔬

Opioid withdrawal is known to be painful, and documented reports of "joint pain" and "rheumatism" during withdrawal date back ~500 years. We speculate that a peripheral inflammatory state contributes to this.

Also, unlike mice, human SGCs express OPRK1. This has been reported before by the Iadarola Lab, which we were able to validate across a few different methods. It probably matters.