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Daniel Diaz
@dddiaz.com

A hard problem in curing Type 1 Diabetes is the immune system. Even if we create new beta cells for someone, transplanting them into someone with #T1D, triggers the immune system to attack them again. This interesting paper www.cell.com/cell-reports...

cell.comCombinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cellsImmune protection of human pluripotent stem cell (hPSC)-derived grafts remains a key hurdle in regenerative medicine. Barra and Robino et al. engineered hPSCs to express an inert bait protein and bait...
Daniel Diaz
@dddiaz.com

Created a gene edited pluripotent stem cell (beta cell precursor, which is what creates insulin) with a bait protein on its surface that can be recognized by something called a CAR-Treg. CAR-Treg (a type of Car-T cell) can suppress immune response. The result being beta cells that survive.

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Daniel Diaz
@dddiaz.com

While only a proof of concept, Its interesting they use #gene editing for both the pluripotent stem cells and the CAR-Treg. #genomics #t1d