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CASS4 is a genetic risk factor for #Alzheimers disease but remains understudied in the brain. Walsh, @lukensjohnr.bsky.social et al. identify CASS4 as a critical regulator of amyloid β plaque compaction, microglial mobilization to damage, and focal adhesion signaling. rupress.org/jem/article/...

Journal of Experimental Medicine

@jem.org

📽️ See a short video summary by the first author, Adeline E. Walsh: youtu.be/KXdNLjwme0I

youtu.beThe Alzheimer's genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosisOriginal paper: [LINK] Video summary by Adeline E Walsh (John Lukens lab, University of Virginia) This study sought to define a role for the Alzheimer’s disease risk gene CASS4 in amyloidosis. We…

27/10/26, 5:30 pm0 reposts0 likes

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