Journal of Experimental Medicine

A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration. New study from Mara Cetty Spinella, Gioacchino Natoli (European Institute of Oncology), Silvia Monticelli @usi.ch et al: rupress.org/jem/article/... #LymphocyteBiology #Tcells #Crohns #IBD #Autoimmunity

📰 #PressRelease: Researchers have discovered that the vitamin derivative pantethine prevents the development of #psoriasis in mice and helps alleviate patient symptoms in a small-scale human trial. www.eurekalert.org/news-release... See the original JEM study: rupress.org/jem/article-...

Cerebrospinal fluid and dural accumulation of α-synuclein impairs CNS clearance in #Parkinsons disease. New study from Taylor J. Stevenson, Justin Rustenhoven and colleagues @aucklanduni.bsky.social: rupress.org/jem/article/... #Neuroinflammation #Neuroscience #InnateImmunity #inflammation

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. From Emily Siniscalco, Courtney Fisher, Meng-Ping Lu, Stephanie Eisenbarth, Uthaman Gowthaman and colleagues: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

Targeting Mettl8-Tcf1 axis promotes CD8⁺ TPEX differentiation and antitumor immunity. From Jiaxi Song, Dan Cui, Qizhao Huang, Jia Li, Fengyin Li, and colleagues: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

Disarming FcR-dependent neutrophil activation in MPO-ANCA #glomerulonephritis. Anne Davidson @northwellhealth.bsky.social discusses new study from Nishide et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/... #InnateImmunity #inflammation #Autoimmunity

Marwa Saad, Angelina Bilate, @danmucida.bsky.social et al. show that colorectal tumors with distinct metastatic potential trigger divergent early T cell responses. rupress.org/jem/article/... #SolidTumors #MucosalImmunology #TumorImmunology #ColonCancer #TCells

Epitope-diverse #autoantibodies induce #neutrophil-epithelial niches driving kidney injury in ANCA-associated #glomerulonephritis. New study from Masayuki Nishide, Atsushi Kumanogoh (University of Osaka) and colleagues: rupress.org/jem/article/... #InnateImmunity #inflammation #Autoimmunity

Inhibitory receptor agonists: Emerging strategies in immune modulation. Review from Kieran R. Adam, Aamir Suhail, @vignalilab.bsky.social and @kuchroolab.bsky.social: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

B7 costimulation antagonizes RORγt+ regulatory #Tcells and immune #tolerance in the intestine. From Mengze Lyu @mengzelyu.bsky.social and Gregory F. Sonnenberg: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

IgD from atypical-like memory #Bcells and #plasmacells targets commensal and environmental antigens. By @rosertp.bsky.social, Bashour, Filipska, @victorgreiff.bsky.social, Cerutti & colleagues: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity. From Shibo Liu, Guanghao Liang, Yayun Yang, Yanyang Shi, Lihui Dong, Peng R. Chen, Meng Michelle Xu and clleagues: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

Regulatory T cells sabotage anti-tumor γδ #Tcells by creating IL-2–deficient environments. From @rafaelblancodom.bsky.social, @bsilvasantos.bsky.social, Sofia Mensurado and colleagues: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

eIF3e-mediated translational checkpoint maintains immune #tolerance and prevents lymphoid malignancy. From Zhengtao Xiao, Dieter A. Wolf, Wen-Hsien Liu, Changchun Xiao and colleagues: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

This collection covers genetic susceptibility to infectious disease, environmental & evolutionary tuning of innate immune responses, neuroimmune regulation of tissue function, metabolic & transcriptional cell-fate control, & #cytokine-mediated tissue protection & repair 👉 rupress.org/jem/collecti...

Are you attending the @cshasia.bsky.social meeting on Immune Tolerance in Suzhou? Get in touch with our Senior Scientific Editor, Zhijuan Qiu @zhijuanjexpmed.bsky.social, who will be there in person! ✉️ Email Zhijuan: rupress.org/jem/pages/ed... Read our collection 👉 rupress.org/jem/collecti...

#Macrophages as programmable integrators of disease tolerance across lifespan. New Viewpoint from Dmitry V. Bulavin @ircan.bsky.social @univcotedazur.bsky.social: rupress.org/jem/article/... #InnateImmunity #inflammation

Scientists co-led by @stjuderesearch.bsky.social have identified a potential therapeutic vulnerability in some forms of #osteosarcoma.: www.stjude.org/media-resour... See the original study by @adurbinlab.bsky.social @junqilab.bsky.social and colleagues here: rupress.org/jem/article/...

Chimeric allergen receptor regulatory #Tcells suppress birch pollen allergic airway #inflammation. From Ana Alcaraz-Serna, Yannick Muller and colleagues: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy. From Alyssa C. Indart, Huiyun Lyu, Qizhi Tang @ucsfdc.bsky.social and colleagues: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

Tumor-reactive LAG3⁺CD8⁺ T cells diverge into terminally exhausted cells and long-lived memory #Tcells. From Vaishali Aggarwal, Yangxi Sun, Chang Liu, Dario Vignali @vignalilab.bsky.social: rupress.org/jem/article/... 📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

Stevenson et al. (rupress.org/jem/article/...) highlight the functional consequence of α-syn aggregates at the brain border, uncovering their active role in reshaping lymphatic integrity and the neuroimmune macroenvironment. Insights from Kim, Munkhbat, and Tischfield: rupress.org/jem/article/...

Zhang et al. @seattlechildrens.org show that Ag-independent IgM BCR signaling restrains human IgM PC differentiation & persistence. Disruption of SYK enhances IgM PC output & persistence, which can be leveraged to improve the durability of engineered IgM-secreting PCs. rupress.org/jem/article/...

Helios is critical for Treg effector differentiation in #adipose #autoimmunity. From Angela M. Thornton, Ethan M. Shevach and colleagues rupress.org/jem/article/... Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...

Explore new collection accompanying @cshasia.bsky.social meeting. These studies reveal mechanisms that shape immune responses to self, commensal, environmental, & tumor antigens and identify new strategies for promoting immune #tolerance or enhancing antitumor immunity 👉 rupress.org/jem/collecti...

Turning cold tumors hot: strategies to enhance antitumor immunity. New review from Viktor German Steffensen, Mojca Bratina, Christina Tsiavou, Kjeld Schmiegelow, and Daniela De Zio (Danish Cancer Institute): rupress.org/jem/article/... #TumorImmunology #Immunotherapy

Researchers at the University of Osaka uncover early changes seen in ANCA-associated glomerulonephritis and investigate a treatment to stop it in its tracks: www.med.osaka-u.ac.jp/eng/activiti... See the original study here: rupress.org/jem/article/...

New research published in @jem.org from @danafarbernews.bsky.social’s Jun Qi, PhD, and collaborators reveals that AKT inhibitors and EP300 degraders positively combine across cancer cells in a manner dependent on control of protein synthesis. Read more here: bit.ly/4z13y9G

Exogenous nitric oxide as an anti-infective agent. New review from Carl F. Nathan @weillcornell.bsky.social: rupress.org/jem/article/... #InnateImmunity #inflammation #InfectiousDisease #HostDefense

Spinella, Natoli, Monticelli @usi.ch et al. linked a #Crohns disease risk allele regulating SKAP2 expression to #Tcell function. SKAP2 enhances cell adhesion while suppressing migration. Sustained TCR signaling triggers its proteolytic cleavage to enable migration. rupress.org/jem/article/... #IBD

Stevenson, Rustenhoven et al. @aucklanduni.bsky.social show that aggregated α-synuclein at CNS borders drives inflammation and impairs lymphatic function, positioning meningeal immunity as a driver of clearance deficits in #Parkinsons disease. rupress.org/jem/article/... #Neuroinflammation

Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1, from Ran Liu, Gengqiao Wang, Zhengting Jiang, Jinyang Gu and colleagues: rupress.org/jem/article/... 📘 Part of our #Cytokines collection: rupress.org/jem/collecti... #Cytokines2026

Herpesvirus CNS infections in genetically heterozygous - transcriptionally homozygous IRF7 deficiency. From Marvin Werner, Trine Mogensen and colleagues: rupress.org/jem/article/... 📘 Part of our #Cytokines collection: rupress.org/jem/collecti... #Cytokines2026

New study from Nishide et al. (rupress.org/jem/article/...) identified activated #neutrophils in kidneys in anti-MPO–associated #vasculitis. Anne Davidson @northwellhealth.bsky.social highlights the findings: rupress.org/jem/article/... #inflammation #Autoimmunity

Masayuki Nishide, Atsushi Kumanogoh et al. identify #neutrophil-epithelial niches linking epitope-diverse anti-MPO #autoantibodies to kidney injury in ANCA-associated #glomerulonephritis, with protection by engineered one-armed antibodies. rupress.org/jem/article/... #inflammation #Autoimmunity

Launching an independent research laboratory and scientific career: Tools for a rapidly changing landscape. New Viewpoint from Simon F. Roy, Amy C. Fan, Nir Hacohen and colleagues: rupress.org/jem/article/...

In this review, Mattison P. Stojcic et al. @turveylab.bsky.social comprehensively discuss known inborn errors of IRFs and how they contribute to our understanding of human biology rupress.org/jem/article/... 📘 Part of our #Cytokines collection: rupress.org/jem/collecti... #Cytokines2026

Does fever drive the #evolution of antiviral genes? Perspective by Ryan Langlois @langloislab.bsky.social: rupress.org/jem/article/... 📘 Part of our #Cytokines collection: rupress.org/jem/collecti... #Cytokines2026

A #circadian checkpoint relocates #neutrophils to minimize injury. From Alejandra Aroca-Crevillén, Andrés Hidalgo @drusqui.bsky.social and colleagues: rupress.org/jem/article/... 📘 Part of our #Cytokines collection: rupress.org/jem/collecti... #Cytokines2026

IFNγ-induced memory in human #macrophages is sustained by the durability of #cytokine signaling itself. From Aleksandr Gorin, Alexander Hoffmann and colleagues rupress.org/jem/article/... 📘 Part of our #Cytokines collection: rupress.org/jem/collecti... #Cytokines2026

#Inflammation rewires the enteric nervous system through neurogenic #monocyte recruitment. From Sravya Kurapati, Changsik Shin, Krisztina Szabo, Milena Bogunovic and colleagues: rupress.org/jem/article/... 📘 Part of our #Cytokines collection: rupress.org/jem/collecti... #Cytokines2026

The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T Cells. From Marco Ongaro, Grégory Verdeil and colleagues: rupress.org/jem/article/... 📘 Part of our #Cytokines collection: rupress.org/jem/collecti... #Cytokines2026