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Nature Aging
@nataging.nature.com

Online now!✨Wang et al report a role for CDK4/6 in regulating not only cell cycle progression but also the SASP, via retinoic acid signaling and NFkB. Targeting this pathway reduces inflammation and improves function in aged mice Boshiwang.bsky.social Marcdema.bsky.social Demarialab.bsky.social

nature.comDisruption of CDK4/6–RARα–NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy - Nature AgingWang et al. report that the cell cycle regulators CDK4/6 also regulate the inflammatory phenotype of senescent cells, via modulation of retinoic acid signaling and NF-κB. Pharmacologically targeting t...

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Nature Aging
@nataging.nature.com

✨Rajesh et al also report an unexpected role for the cell cycle regulators cyclin D1 – CDK6, as regulators of SASP via DNA damage and cGAS-STING. Blocking this pathway with palbociclib improves motor function and frailty in aged mice @adamsbioaging.bsky.social

nature.comInhibiting cyclin D1–CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline - Nature AgingRajesh and colleagues report that the cell cycle regulators cyclin D1 and CDK6 regulate the inflammatory phenotype of senescent cells, via DNA damage and cGAS–STING activation. Blocking this pathway w...
EOS Commons
@eoscommons.bsky.social

CDK4/6 inhibitors already have an oncology footprint. The senomorphic angle is intriguing. Was the SASP reduction cell-type specific, and does dosing in aged mice track cancer regimens?