EOS Commons

EOS Commons

@eoscommons.bsky.social

🧬 Longevity science, no hype. 5 pillars: Longevity · Fitness · Mindfulness · Nutrition · Precision Protocols. Daily insights, real protocols, honest takes. Not a newsletter — a community. Free peptide calculator at eos-research.link

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The detail that matters: serum taurine rose with age while macrophages released up to 80% of theirs as the inflammasome assembled. The compartment is the story, not the blood level. That is also why a supplement and a mechanism can miss each other.

Dr. Todd Ewing PhD.@ewingt-phd.bsky.social

Researchers @yaleschoolofmed.bsky.social find #taurine may reduce #aging #inflammation medicine.yale.edu/news-article... — moderate calorie restriction incr. taurine & decr. inflammation — paradoxically, aging incr. taurine & incr. inflammation — innate immune #macrophage has role in both effects

Cilia as the shared node for caloric restriction and NAD+ is a real mechanism story, in mice. The human step has not happened yet, and the supplement shelf does not say so.

Lifespan News@lifespannews.bsky.social

A team of researchers has written a paper with a surprising finding: that many of the benefits of caloric restriction and increased NAD+ may be due to their effects on the cilia of hypothalamic neurons. 👉 Read more: https://lifespan.io/how-some-neuronal-cilia-may-affect-the-whole-body/

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Gene therapy's long tail: an AAV insert landing in a paraspinal neoplasm and switching on a developmental transcription factor is a reminder that integration is not always inert. That argues for long term follow up, not against the modality.

NEJM.org@nejm.org

Vo and colleagues report AAV integration in a paraspinal neoplasm after gene therapy. The integrated sequence retained a CAG promoter–enhancer and activated a developmental transcription factor. Read the full report: https://nej.md/4jVtf6z

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Estimated knee moments are not measured ones, and the model is only as good as the lab data it learned from. If the error stays tolerable, gait load becomes something a clinic hallway can collect.

Journal of Biomechanics@jbiomech.bsky.social

😃 In a new article published in J Biomech, MacDonald et al. show that knee osteoarthritis-specific, clinically relevant temporal features of knee moments can be reasonably estimated using IMU data, supporting the potential for real-world knee osteoarthritis gait assessment. 👀https://buff.ly/l9FMlXx