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Antibiotic resistance evolution: A systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptide @mulkern.bsky.social @mgalactus.bsky.social @twincore.bsky.social @helmholtzhzi.bsky.social @helmholtz-hiri.bsky.social
dlvr.itA systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptide - Nature CommunicationsIn this study, authors investigate the evolution of bacterial resistance to antisense peptide nucleic acid (PNA) antibiotics. They observe that this typically occurs mainly by reducing drug uptake via mutations in the carrier peptide’s transporter, while resistance to a different carrier peptide stayed low and is easily bypassed by tweaking the drug sequence.
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