Nature Communications

dlvr.itSevuparin in children with severe malaria: a phase I safety and dose-finding trial - Nature CommunicationsThis trial demonstrates the safety of sevuparin, a heparin-like compound, as an adjunctive therapy in severe malaria in African children and identified, using a continual reassessment method design, the optimal dose to investigate in future trials.

3h

#Malaria Sevuparin in children with severe malaria This phase I trial demonstrates the safety of sevuparin (a heparin-like compound) as an adjunctive therapy in severe malaria in African children, and identifies the optimal dose to investigate in future trials @kathmaitland.bsky.social

dlvr.itResearchers uncover new way deadly fungus Candida auris evades treatment | City St George's, University of LondonCity St George’s researchers, working with the University of Exeter, have discovered an unexpected new mechanism that allows the deadly fungal pathogen Candida auris to survive antifungal treatment.

1d

#Mycology Researchers uncover new way deadly fungus Candida auris evades treatment "the study found that Candida auris can create multiple versions of its entire genome and develop mutations that help it withstand treatment" #fungi #AntimicrobialResistance #AMR

#WastewaterSurveillance An analysis of wastewater #metagenomics & antibiotic use data reveals a variable lagging association between human antibiotic consumption & antibiotic resistance genes in sewage bacteria #AMR #AntibioticResistance http://dlvr.it/TW03H2

dlvr.itViral Protein Helps Self-Amplifying RNA Overcome Cellular DefensesThe finding may make it possible to launch saRNA vaccines faster for use in gene therapy, cancer immunotherapy, and protein replacement.

#Vaccines Viral Protein Helps Self-Amplifying RNA Overcome Cellular Defenses “if this translates successfully in vivo, it could open new possibilities for vaccine design as well for gene therapies and cancer treatment” @maillardlab.bsky.social

dlvr.itQueen Mary scientists overcome key barrier to self-amplifying vaccinesThe innovation could enable protection at lower doses, meaning vaccines could be rolled out further and faster than was previously imaginable, and opens new possibilities in gene therapy, cancer immunotherapy, and protein replacement therapies.

#Vaccines Scientists overcome key barrier to self-amplifying RNA vaccines They found a way to overcome cell’s natural defences against mRNA vaccines, allowing them to produce more of their target protein This could enable protection at lower doses @maillardlab.bsky.social

dlvr.itCall for papers: The status of infectious diseases in Latin America: emerging, endemic, and multimorbidity

Call for papers: The status of infectious diseases in Latin America and the Caribbean: emerging, endemic, and multimorbidity

dlvr.itViral Protein Helps Self-Amplifying RNA Overcome Cellular DefensesThe finding may make it possible to launch saRNA vaccines faster for use in gene therapy, cancer immunotherapy, and protein replacement.

#Vaccines Viral Protein Helps Self-Amplifying RNA Overcome Cellular Defenses “if this translates successfully in vivo, it could open new possibilities for vaccine design as well for gene therapies and cancer treatment” @maillardlab.bsky.social

Nature Communications reposted

Maillard Lab

@maillardlab.bsky.social

nature.comTuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity - Nature CommunicationsThis study shows that expressing the viral protein B2 in self-amplifying RNA overcomes innate antiviral defences, boosting transgene expression while preserving immune-stimulating properties.

Delighted to share a new paper from my lab in Nature Communications ! 🎉 Nodamura virus B2 enhances self-amplifying RNA activity while preserving its immune-stimulating properties. Led by @rayusanda.bsky.social with equal contributions from Josephine Nemegeer and @jerryhoang.bsky.social 👇

dlvr.itRapid Whole Genome Sequencing Enhances Pediatric Cancer Diagnosis - Nature CommunicationsWhole-genome sequencing (WGS) can provide important benefits to childhood cancer patients, but clinical WGS workflows typically take weeks. Here, the authors evaluate the feasibility and efficacy of a rapid WGS research workflow with streamlined bioinformatics, reducing the mean turnaround time from 42 to 3 days without sacrificing the detection of clinically actionable variants.

Vedi et al. show the feasibility and efficacy of a rapid whole-genome sequencing workflow for childhood #cancer patients, reducing mean turnaround time from 42 to 3 days and improving detection of clinically actionable variants #CanSky #OncoSky

#WastewaterSurveillance An analysis of wastewater #metagenomics & antibiotic use data reveals a variable lagging association between human antibiotic consumption & antibiotic resistance genes in sewage bacteria #AMR #AntibioticResistance http://dlvr.it/TVvzxl

dlvr.itOne Question, Millions of Cells: How MALVINA Was BornA simple question and millions of single-cell measurements led us to rethink how bacterial virulence should be measured.

One Question, Millions of Cells: How MALVINA Was Born "Like many projects, ours began with a carefully written research plan. But some of its most important turns came from a conversation..., a chance encounter..., and a deceptively simple question from a PhD student" @thelazarlab.bsky.social

dlvr.itQueen Mary scientists overcome key barrier to self-amplifying vaccinesThe innovation could enable protection at lower doses, meaning vaccines could be rolled out further and faster than was previously imaginable, and opens new possibilities in gene therapy, cancer immunotherapy, and protein replacement therapies.

#Vaccines Scientists overcome key barrier to self-amplifying RNA vaccines They found a way to overcome cell’s natural defences against mRNA vaccines, allowing them to produce more of their target protein This could enable protection at lower doses @maillardlab.bsky.social

Nature Communications reposted

nmaslac.bsky.social

@nmaslac.bsky.social

nature.comMolecular basis of N2 fixation in a hyperthermophilic archaeon - Nature CommunicationsNitrogenases are enzymes that convert atmospheric N2 into ammonia, thus providing bioavailable nitrogen to living organisms. Here, Maslać et al. describe a highly thermostable, simple nitrogenase from...

Our story about molecular adaptive traits of hyperthermostable archaeal nitrogenase is now out in @natcomms.nature.com !🦠🔍 www.nature.com/articles/s41...

dlvr.itHigh-throughput spatial proteomics from cellular to subcellular scales via a hanging droplet workflow - Nature CommunicationsFormalin-fixed paraffin-embedded (FFPE) samples are central for clinical research and spatial proteomics. Here, the authors present a streamlined micro-FFPE proteomics workflow that enables rapid, high-throughput spatial proteomics of laser-capture microdissected tissue.

Researchers at @jesperolsenlab.bsky.social develop a simple, scalable hanging-droplet workflow enables efficient, high-throughput protein profiling of small tissue regions #SpatialProteomics #Proteomics #MassSpectrometry #FFPE

Nature Communications reposted

Nature Reviews Microbiology

@natrevmicro.nature.com

8 Sept

ICYMI: New online! Fungal Starship transposons for interspecies gene transfer

dlvr.itFungal Starship transposons for interspecies gene transferNature Reviews Microbiology, Published online: 01 September 2026; doi:10.1038/s41579-026-01361-4Fungal Starship transposons for interspecies gene transfer

dlvr.itOne Question, Millions of Cells: How MALVINA Was BornA simple question and millions of single-cell measurements led us to rethink how bacterial virulence should be measured.

One Question, Millions of Cells: How MALVINA Was Born "Like many projects, ours began with a carefully written research plan. But some of its most important turns came from a conversation..., a chance encounter..., and a deceptively simple question from a PhD student" @thelazarlab.bsky.social

Nature Communications reposted

TheLazarLab

@thelazarlab.bsky.social

communities.springernature.comOne Question, Millions of Cells: How MALVINA Was BornA simple question and millions of single-cell measurements led us to rethink how bacterial virulence should be measured.

MALVINA is not just a method for us, but a story of questions, teamwork, coffee and millions of cells. We wrote down how the project grew from one simple question into a @natcomms.nature.com study. Read the Behind the Paper story, and follow us communities.springernature.com/posts/one-qu...

nature.comGlobal climate impact of land-surface change driven by radiative effects - Nature CommunicationsThis study shows that the integrated temperature response to land-surface change scales linearly with the resultant shift in planetary albedo, demonstrating that non-radiative effects — which determin...

New study shows that the #temperature response to land-surface change scales linearly with the resultant shift in planetary #albedo, demonstrating that non-radiative effects cancel out at the global scale. www.nature.com/articles/s41...

nature.comPhenological fluctuations induce seasonal asymmetric warming in boreal forests - Nature CommunicationsThis study uses satellite data and shows that in boreal forests the warming from seasonal leaf area loss outweighs the cooling from an equivalent gain. This asymmetry is driven by transpiration limits...

New study shows that #warming from seasonal leaf area loss outweighs the cooling from an equivalent gain in #BorealForest. This asymmetry is driven by #transpiration limits in the growing season, and by canopy-snow #albedo contrasts in winter. #RemoteSensing www.nature.com/articles/s41...

Nature Communications reposted

Anjali Sharma

@anjalisharma.bsky.social

@natureportfolio.nature.com

Collection celebrating the 2026 #NobelPrize in #Physics is now live! @natcomms.nature.com

Nature Portfolio@natureportfolio.nature.com

The 2026 Nobel Prize in Physics has been awarded to Francis Halzen "for decisive contributions to the IceCube Neutrino Observatory and the discovery of high-energy neutrinos of astrophysical origin." This collection celebrates the achievement. go.nature.com/4hIf4iN ⚛️🔭🧪

Nature Communications reposted

Nature Portfolio

The 2026 Nobel Prize in Physics has been awarded to Francis Halzen "for decisive contributions to the IceCube Neutrino Observatory and the discovery of high-energy neutrinos of astrophysical origin." This collection celebrates the achievement. go.nature.com/4hIf4iN ⚛️🔭🧪

Nature Communications reposted

TheLazarLab

@thelazarlab.bsky.social

nature.comDeep-learning single-cell profiling uncovers interbacterial and drug-driven reshaping of pathogen virulence - Nature CommunicationsThis study introduces MALVINA, a deep-learning platform that measures bacterial invasion and DNA damage in individual human cells, revealing how bacterial interactions and commonly used drugs reshape ...

Counting bacteria is not enough. To understand what makes a bacterium dangerous, we need to see what it actually does when it meets human cells. Our MALVINA study is now out in @natcomms.nature.com www.nature.com/articles/s41...

dlvr.itNature CommunicationsNature Communications is an open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, ...

New featured image on our website! http://dlvr.it/TVpS9W Related to this article by Sophie van ’t Hof et al @pregnancybrainlab.bsky.social : Puberty, pregnancy, and menopause show shared and distinct structural changes across the lifespan http://dlvr.it/TVpS9Y

Nature Communications reposted

Institut Jacques Monod

@ijmonod.bsky.social

✍️ The Bonazzi Lab published a new article 📖 @natcomms.nature.com 📃Bacterial growth under confinement requires transcriptional adaptation to resist turgor pressure build-up 🔗 www.nature.com/articles/s41...

doi.orgIAP antagonist tolinapant (ASTX660) in combination with pembrolizumab in advanced solid tumors: a phase I trial - Nature CommunicationsThe IAP antagonist ASTX660 has the potential to enhance cancer immunotherapy by sensitizing tumour cells to immune-mediated killing. Here, the authors report results from an open-label, multicentre ph...

Results from an open label, multicenter phase I #trial evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of #ASTX660 in combination with the anti-PD-1 antibody #pembrolizumab for solid #tumors doi.org/10.1038/s414...

Nature Communications reposted

Institut Pasteur | 130 years of biomedical research

@pasteur.fr

🤖 New AI can "see" antibiotic action on bacteria through microscopy alone—detecting effects invisible to standard tests. A breakthrough that could accelerate antibiotic discovery & combat resistance. 🔬 📖 www.pasteur.fr/en/whats-new...

dlvr.itCryo-EM structures of autoinhibited and RNA-activated ZNFX1 helicase - Nature CommunicationsZNFX1 is an RNA helicase that plays a critical role in host defense against viral infections. Here, the authors reveal how RNA binding remodels autoinhibited ZNFX1 assemblies and activates the helicase for ATP-dependent RNA unwinding.

Researchers @vai.org reveal how RNA binding remodels autoinhibited ZNFX1 assemblies and activates the helicase for ATP-dependent RNA unwinding

dlvr.itOrthosteric and allosteric inhibition of the brain V-ATPase outside the alternating-access cycle - Nature CommunicationsV-ATPases are proton pumps that acidify synaptic vesicles and intracellular compartments. Here, authors show that several inhibitors mainly switch individual brain V-ATPases into long-lived inactive states instead of slowing proton pumping rates.

Researchers led by @illumbiotech.bsky.social report insights into mechanisms of brain V-ATPase inhibition

dlvr.itMultiplexed deep visual proteomics resolves spatial heterogeneity and rare endocrine states in human pancreatic islets - Nature CommunicationsLinking spatial context to molecular depth in tissue remains difficult. Here, the authors combine high-plex imaging, open-source image analysis and ultra-sensitive mass spectrometry to profile single endocrine cell types in human pancreatic islets, including rare bi-hormonal and polyhormonal states.

@mari-mardamshin.bsky.social and colleagues combine high-plex imaging, open-source image analysis and ultra-sensitive mass spectrometry to profile single endocrine cell types in human pancreatic islets

dlvr.itNature CommunicationsNature Communications is an open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, ...

New featured image on our website! http://dlvr.it/TVnD10 Related to this article by Sophie van ’t Hof et al @pregnancybrainlab.bsky.social : Puberty, pregnancy, and menopause show shared and distinct structural changes across the lifespan http://dlvr.it/TVnD1B

Nature Communications reposted

Daniel Krentzel

@danielkrentzel.bsky.social

nature.comDeep learning recognises antibiotic modes of action from brightfield images - Nature CommunicationsAuthors present a deep learning model that recognises antibiotic modes of action (MoA) directly from brightfield images. Their proposed method complements traditional growth inhibition assays in the s...

Super excited to see the first research article from my PhD @pasteur.fr out in @natcomms.nature.com! Here's a thread on the key results 🧵 @chzimmer.bsky.social @kelvinkho.bsky.social @curieuseny.bsky.social @awehenkel.bsky.social @ivo-boneca.bsky.social www.nature.com/articles/s41...

dlvr.itDivergent microbial functional pathways and declining redundancy in lake sediments across eutrophication gradients - Nature CommunicationsIn this study, the authors conduct a metagenomic study of 144 Aotearoa-New Zealand lakes to show that eutrophication impacts the functional redundancy of metabolic functions in surface sediment microbes, by narrowing of the species pool, although abundance shifts could offer some resilience.

Microbial ecology: A metagenomic study of 144 Aotearoa-New Zealand lakes shows that eutrophication impacts the functional redundancy of metabolic functions in surface sediment microbes by narrowing of the species pool, although abundance shifts could offer some resilience @jkpearman45

dlvr.itDivergent microbial functional pathways and declining redundancy in lake sediments across eutrophication gradients - Nature CommunicationsIn this study, the authors conduct a metagenomic study of 144 Aotearoa-New Zealand lakes to show that eutrophication impacts the functional redundancy of metabolic functions in surface sediment microbes, by narrowing of the species pool, although abundance shifts could offer some resilience.

Microbial ecology: A metagenomic study of 144 Aotearoa-New Zealand lakes shows that eutrophication impacts the functional redundancy of metabolic functions in surface sediment microbes by narrowing of the species pool, although abundance shifts could offer some resilience @jkpearman45

dlvr.itBiofilm formation and dynamics in the marine cyanobacterium Prochlorococcus - Nature CommunicationsIn this study, the authors show that Prochlorococcus picocyanobacteria form biofilms and dynamically transition between free-living and attached states with significantly different physiology, thus suggesting a role for these bacteria in deep-ocean carbon export.

Prochlorococcus cyanobacteria form biofilms on particles & dynamically transition between free-living and attached states with significantly different physiology That impacts carbon release, thus suggesting a role in carbon export to the deep sea @mitcee.bksy.social #phytoplankton #biofilm #oceans

nature.comSix-fold reduction in ocean heat content estimate uncertainty since 1960 - Nature CommunicationsThis study presents a comprehensive quantification of ocean heat content uncertainty since 1960 and shows a six-fold reduction in the global upper-2000m uncertainty in the last decade and a robust oce...

New study presents a comprehensive quantification of #ocean #heat content uncertainty since 1960 and shows a six-fold reduction in the global upper-2000m uncertainty in the last decade and a robust ocean #warming. www.nature.com/articles/s41...

dlvr.itFive-country analysis of geographic and dietary drivers of gut microbiome composition and genomic variation - Nature CommunicationsIn this study, authors show that human gut microbiome composition and microbial genomes vary strongly across five industrialized countries, with diet microbiome links that are partly shared but largely population-specific.

#Microbiome Human gut microbiome composition and microbial genomes vary strongly across 5 industrialized countries. Diet-microbiome links are partly shared but largely population-specific. The Human Diets and Microbiome Initiative (THDMI) #nutrition #PrecisionNutrition

dlvr.itA divergent betacoronavirus with a functional furin cleavage site in South American bats - Nature CommunicationsThere is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American bats, expanding knowledge of coronavirus diversity and features linked to zoonotic potential.

#Virology A divergent betacoronavirus with a functional furin cleavage site in South American bats The study provides a broader understanding of the diversity of bat coronaviruses, offering evolutionary context for features that may be relevant to zoonotic potential @kosuke-takada.bsky.social

dlvr.itBiofilm formation and dynamics in the marine cyanobacterium Prochlorococcus - Nature CommunicationsIn this study, the authors show that Prochlorococcus picocyanobacteria form biofilms and dynamically transition between free-living and attached states with significantly different physiology, thus suggesting a role for these bacteria in deep-ocean carbon export.

Prochlorococcus cyanobacteria form biofilms on particles & dynamically transition between free-living and attached states with significantly different physiology That impacts carbon release, thus suggesting a role in carbon export to the deep sea @mitcee.bksy.social #phytoplankton #biofilm #oceans

nature.comRecent globally synchronous seasonal warm events unprecedented since 850 CE - Nature CommunicationsThis study shows that the extremity of globally synchronized seasonal warm events has sharply intensified in recent decades, reaching unprecedented levels since 850 CE, largely driven by anthropogenic...

New study shows that the extremity of globally synchronized seasonal warm events has sharply intensified in recent decades, reaching unprecedented levels since 850 CE, largely driven by anthropogenic greenhouse gas forcing. #ClimateChange www.nature.com/articles/s41...

nature.comA Hadean timeline for the emergence of the RNA World - Nature CommunicationsA 3-D thermal model identifies a ~ 4.33 Ga temporal “sweet spot” for life’s origin, when decreased bombardment enabled mild hydrothermal niches to support RNA World chemistry and stable biomolecu...

A 3-D thermal model identifies a ~ 4.33 Ga temporal “sweet spot” for life’s origin, when decreased bombardment enabled mild hydrothermal niches to support RNA World chemistry and stable biomolecule preservation, congruent with LUCA estimates. www.nature.com/articles/s41...

dlvr.itFive-country analysis of geographic and dietary drivers of gut microbiome composition and genomic variation - Nature CommunicationsIn this study, authors show that human gut microbiome composition and microbial genomes vary strongly across five industrialized countries, with diet microbiome links that are partly shared but largely population-specific.

#Microbiome Human gut microbiome composition and microbial genomes vary strongly across 5 industrialized countries. Diet-microbiome links are partly shared but largely population-specific. The Human Diets and Microbiome Initiative (THDMI) #nutrition #PrecisionNutrition

doi.orgChronic stress activates a hypothalamic vagal circuit to promote hepatocellular carcinoma progression in male mice - Nature CommunicationsChronic stress can promote hepatocellular carcinoma (HCC) progression. Here, the authors show in mice that chronic stress activates a brain-liver signaling circuit that mediates tumor epithelial-macro...

Chronic #stress shown to activate a brain-liver signalling circuit that mediates tumour epithelial-macrophage crosstalk and promotes #hepatocellular carcinoma growth #cancerneuroscience doi.org/10.1038/s414...

dlvr.itA divergent betacoronavirus with a functional furin cleavage site in South American bats - Nature CommunicationsThere is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American bats, expanding knowledge of coronavirus diversity and features linked to zoonotic potential.

#Virology A divergent betacoronavirus with a functional furin cleavage site in South American bats The study provides a broader understanding of the diversity of bat coronaviruses, offering evolutionary context for features that may be relevant to zoonotic potential @kosuke-takada.bsky.social

Nature Communications reposted

Kosuke Takada

@kosuke-takada.bsky.social

5 Sept

We’re delighted to share that our paper on a highly divergent betacoronavirus from a South American bat that encodes a functional furin cleavage site is now published. 🦇🦠 Another fascinating reminder of the remarkable diversity of coronavirus evolution in wildlife. 🔗　doi.org/10.1038/s414...

doi.orgA divergent betacoronavirus with a functional furin cleavage site in South American bats - Nature CommunicationsThere is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American ba...

dlvr.itDeep learning recognises antibiotic modes of action from brightfield images - Nature CommunicationsAuthors present a deep learning model that recognises antibiotic modes of action (MoA) directly from brightfield images. Their proposed method complements traditional growth inhibition assays in the search for novel antibiotics.

#Antibiotics A deep-learning model recognises antibiotic modes of action using unlabelled brightfield images of drug-treated bacteria @chzimmer.bsky.social @pasteur.fr @uni-wuerzburg.de @danielkrentzel.bsky.social @kelvinkho.bsky.social @awehenkel.bsky.social #deeplearning #AI4AMR #microbiology

Nature Communications reposted

LabEx ParaFrap

@parafrap.bsky.social

17 Sept

🎉 Great news from the LabEx community! A study on #Trypanosoma transmission has been selected among 50 outstanding papers for @natcomms.nature.com Editors’ Highlights in Microbiology & Infectious Diseases! 🦠 👏 Congrats to the team! 🔗 Discover the story & the research 👇

linkedin.comGlycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions - Nature Communications | Frédéric BringaudI am delighted to share that our article, “Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions,” has been selected by the editors of N...

Nature Communications reposted

Max Planck Institute for Marine Microbiology

@mpimarinemicrobio.bsky.social

16 Sept

Scientists have purified a heat-stable and possibly ancient N2-fixing enzyme from a deep-sea archaeon. They caught the Mo-containing enzyme in a turnover state, highlighting a universal principle among nitrogenases. @natcomms.nature.com mpi-bremen.de/en/Page6804.... www.nature.com/articles/s41...

dlvr.itA systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptide - Nature CommunicationsIn this study, authors investigate the evolution of bacterial resistance to antisense peptide nucleic acid (PNA) antibiotics. They observe that this typically occurs mainly by reducing drug uptake via mutations in the carrier peptide’s transporter, while resistance to a different carrier peptide stayed low and is easily bypassed by tweaking the drug sequence.

22 Sept

Antibiotic resistance evolution: A systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptide @mulkern.bsky.social @mgalactus.bsky.social @twincore.bsky.social @helmholtzhzi.bsky.social @helmholtz-hiri.bsky.social