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Nature Communications

@natcomms.nature.com

Researchers led by @illumbiotech.bsky.social report insights into mechanisms of brain V-ATPase inhibition

dlvr.itOrthosteric and allosteric inhibition of the brain V-ATPase outside the alternating-access cycle - Nature CommunicationsV-ATPases are proton pumps that acidify synaptic vesicles and intracellular compartments. Here, authors show that several inhibitors mainly switch individual brain V-ATPases into long-lived inactive states instead of slowing proton pumping rates.

6/10/26, 9:06 am3 reposts1 like

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