Post

Craig Kaplan
@triggerloop.bsky.social

Amazing physical chemical analysis of chromosome condensation and decondensation from Andrew Beel, PJ Mattei, and Roger Kornberg. I was tickled to see some expressions that I am used to from Roger's writing in the paper www.science.org/doi/10.1126/...

science.orgThe eukaryote chromosome, a two-state system with interconversion by a volume phase transitionThe formation of metaphase chromosomes requires the activity of condensins, DNA translocases that reduce chromosomal length through the process of loop extrusion. Reduction of length, however, does no...

6 reposts17 likes

Hannes
@hwitt.bsky.social

It caused a weird thing where the publication about the phenomenon comes out two years after our study on the impact of that phenomenon on chromosome mechanics www.nature.com/articles/s41...

nature.comIon-mediated condensation controls the mechanics of mitotic chromosomes - Nature MaterialsThe physical mechanisms that govern chromosomal viscoelasticity remain elusive. Here the authors combine single-chromosome manipulation and computational methods to show that their collective properti...
Craig Kaplan
@triggerloop.bsky.social

This project looks like it was Andrew’s DP5 work - though I feel everyone must have worked together on it. Just want to give credit on the theoretical work to Andrew as the paper indicates. But recognizable touches to me from Roger were in the writing