Nicholas Mancuso

"AI often misses big pictures. This is not because AI lacks knowledge but because it lacks taste." 🔥

bring back shame for being a huge fucking racist in public

Out today in Nature Genetics: “Quantification method affects replicability of eQTL analysis, colocalization and TWAS,” led by outstanding postdoc @taylorhead.bsky.social at @mdanderson.bsky.social. This was a full lab effort, and I'm proud of them all for their hard work! rdcu.be/a2jiWvAMFaVa

Excited to share our new @nathumbehav.nature.com paper reporting within-family heritability estimates (the gold standard design unconfounded with population stratification, shared environmental effects and assortative mating) from 500,000 siblings pairs of diverse ancestries.

Thanks to all @23andMe participants and our amazing co-authors: Yanyu Liang, Julie Granka, Xin Wang, Julia Sidorenko, David Evans and Peter Visscher. Please check it out and share! Link: www.nature.com/articles/s41...

Reminder.. The SF Chronicle on Prop 38: “Prop 38 is one of the most noxious deposits on California’s political dung heap in years. See votenoonprop38.org/newsroom/sf-... VOTE NO ON 38. VOTE NO ON 38. VOTE NO ON 38. VOTE NO ON 38. VOTE NO ON 38. VOTE NO ON 38. VOTE NO ON 38. VOTE NO ON 38.

The world needs a high-quality, truly open language model. I wrote about why it’s necessary and why it’s easier to build than you might think.

Teenage Nick: Rock the Casbah was a cheap attempt at commercial success for the Clash and their worst song Middle age Nick: ha ha, I love how frolicky the piano is

This. And if most Americans weren't aware of this in 2019, I'd guess they're even less so now. Public university students were paying for a third of the cost of their education in 2009, and it was up to half by 2019. 2009 wasn't great compared to the 60s-70s, either. www.pbs.org/newshour/edu...

*flying home to LA* My Poincare shirt has a lotta people asking questions about shortest path home already answered by my shirt

Away just long enough to start getting taco withdrawals

Home

“But if you just vibe code up your entire special snowflake engine your product will be a buggy mess you’ll have to spend forever patching” so like every game that’s been released for the past 15 years but at 1/100th the price?

🎶Blinded by the light🎶

Doing the work to deconstruct other’s writing and reconstruct it is what allows you to see holes or structural issues in your own

Another cost/benefit aspect I've been mulling about: say we use AI to develop some scientific software or tool that is orders of magnitude faster than existing tools. It comes with an initial energy /env cost due to AI use, but would sig reduce downstream env cost for scientific computation

Given the shift in media ownership over the Trump era, Democrats REALLY need to learn to ignore media handwringing now. Because I have no doubt their every move for accountability will be attacked from every possible angle.

Haplotype-based fine-mapping of variant associations for complex traits https://www.biorxiv.org/content/10.64898/2026.10.19.760226v1

it continues to be funny to me when i hear people go "but obviously these dsa types just want to destroy the market and implement stalinism" while, meanwhile, they are actually *more* pro-market than the mainline democrat incumbents they're challenging

LA mayoral candidate Nithya Raman says fewer than 10% of new LA homes are for sale because for-sale projects face higher fees, tougher approvals, easier appeals, and greater liability risk. www.realtor.com/news/real-es...

A wonderful @geneticssociety.bsky.social in beautiful Montreal 🍁

We are hiring a tenure-track assistant professor in computational biology at USC! area: AI method development and its applications in biology. Do you combine quantitative research with a drive to develop innovative approaches for tackling biological questions? usccareers.usc.edu/job/los-ange...

arxiv.org/abs/2610.31642

Notes on Kimi K3.1 - this one is a big deal, the first time an open weights (well, soon-to-be open weights) model has competed this credibly with the current frontier simonwillison.net/2026/Oct/23/...

Helping authors improve their papers is not the purpose of peer review.

I am so excited for this conference. A stellar line-up of incredible researchers across disciplines, a beautiful location, and a great environment for younger scientists. And what a treat that I get to co-organize this with @levine-lab.bsky.social! www.grc.org/molecular-me...

This seems very cool

Congratulations to the winners of the HGG Advances Awards for Outstanding Early Career Publication, as chosen by the @hggadvances.bsky.social editorial board, Quan Sun and Cindy Thomas-Charles! #ASHG26

edgePython v0.5.0 released at github.com/pachterlab/e... (`pip install edgepython`) Matches the forthcoming edgeR 5.0 with several extra features as well as some edgeR bugs avoided. Major speedups (4-6x faster, camera >100x), I/O improvements, and proper support for kallisto.

Bikes allowed? Cherry allowed? What in the world am I looking at here Montreal

"Wicked Witch of the east, bro" , but literally any academic topic

Joshua Popp presenting really cool work on improving seq2func models using allele freq and ld score to calibrate #ashg2026

Ok Montreal I wasn't aware of ur egg tart game

Evan and Javier organized special session on mutagenesis, and I am very happy be presenting on it tomorrow morning. Alongside big headliners like @mollyprz.bsky.social, @s-j-aitken.bsky.social and Martin Santamarina #ashg2026

Excited for the first full day at #ASHG26? Come see Thorkild Terkelsen (@thorkildterkelsen.bsky.social), featured in our InsideAJHG series, talk about his recently published work on "3D regulatory rewiring of SOX3 by an interchromosomal insertion causes spastic paraplegia" in room 510 at 11:00 AM!

I'll be at #ASHG2026 this year! I'm presenting some recent work (with @huishengzhu.bsky.social) on extracting all the information we can out of rare-variant burden test statistics for downstream meta-analysis. Catch me at poster 8357F to talk about the project or stat gen / pop gen.

Its fair game to criticise AI use for its energy costs, but I do think those in the biomedical field leveling those criticisms should consider what environmental impact a -80 has, or of reagent production and delivery. It can help put things into perspective just a touch

MancusoLab has two talks at #ASHG2026, please come check them out! Thursday, 8:30am; Scalable fine-mapping of single-cell eQTL data using variational count-based models Saturday, 9:00am; An end-to-end differentiable, inferential model of stabilizing selection for molecular quantitative traits

Star and director of You Can See Everything Nathan Fielder explains his decision to appear in the film with the ex Theranos CEO. tinyurl.com/2x22bpvy

Goodbye Stranger by Supertramp is such a classic. All time feel good song.

Super excited to share our new preprint with Jacob Mueller, David Reich & colleagues! Also my first project beyond humans/primates. We usually study admixed genomes as evolutionary end products. So what happens in the first few generations after hybridization? www.biorxiv.org/content/10.6...