Adam Marblestone

Hello world! We’re @melodyfro.bsky.social Most wearables don’t go far beyond heart rate and activity. Lab diagnostics paint a deeper picture but don’t read continuously. Melody is building biosensors, devices, and standards to bridge this gap. Hear our story at melodyfro.org

www.smithsonianmag.com/science-natu...

With a lens array in Chile, astronomers capture clumps of gas from a dying star returning to the Galaxy. Learn more: https://scim.ag/4g6qThX

New telescope reveals a missing link in the cosmic recycling of matter | Science | AAAS 🔭🧪 @science.org www.science.org/content/arti...

Go Dragonfly FRO!

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Previously, Science broke the news that NSF would be clawing back money, and attributed it to the 10-year, 1.5 billion X-Labs initiative. We have an official denial from NSF, and internal budget numbers for the X-Labs account suggest it will only spend $50 million this year, all from TIP's budget.

State adds to funding promises for National Science Foundation X-Labs research groups https://www.nashvillepost.com/tennessee-investing-3-million-into-quantum-teams/article_0504570c-5509-4f7f-bd7c-a5d81018e67b.html

ASM has submitted formal comments urging the White House Office of Management and Budget to withdraw a proposed rule that would weaken the peer review process, limit scientific collaboration and networking and create new barriers to conducting and disseminating research: asm.org/articles/pol...

We've been checking with contacts inside the NSF and they are saying this is wildly inaccurate. X-labs is not anywhere close to big enough to make up this hole. As far as I have heard, this program is coming out of TIP specific funding

Today we're launching Deliverome Bio, a focused research organization tackling one of the biggest bottlenecks in medicine: getting therapeutics to tissues beyond the liver.

Introducing GLOBE—a new technology for brain-wide, single-cell recording of cellular activity in vivo. GLOBE can continuously record from nearly a quarter million individual neurons simultaneously across a mouse brain. Preprint out on bioRxiv: doi.org/10.64898/202... 🧵(1/6)

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Seeking teams to test whether AI-enabled formal methods can make high-assurance cyber defense practical, at scale, through building production-grade software components backed by machine-checked proofs and validated through coordinated red-team exercises. https://bit.ly/49Wif30

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Agreed re the cortical column Markram targeted, but I think connectomics could be hugely beneficial to study of areas like hypothalamus, where we have evolutionarily wired "artisanal" circuits implementing very specific rules for how different drives interact with each other :)

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Full proposals are now open for our Massively Scalable Neurotechnologies programme. Led by Jacques Carolan, we are investing £50m to develop a new class of neurotech – interfaces that reach the brain via the body’s natural pathways. Submit by 11 May: link.aria.org.uk/MSNx

Our latest publication grapples with how the brain could implement gradient descent by sending learning targets top-down, gating plasticity with dendritic inhibition, and updating synaptic weights with biologically observed learning rules like BTSP. www.cell.com/cell-reports...

First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...

The Sweet Lesson of Neuroscience

Terence Tao on how math is changing, #formalverification as the enabler of scaled human-AI collaboration: "The reason why scaling and AI and broad participation actually is a net win is because we have formal verification." 📺 www.youtube.com/watch?v=SuTx... #leanlang #leanprover

We've just added a new FRO to our website! In this Essential Technology piece, we share three three principles from CHI-FRO, an engineering-heavy partnership to build out tools for probabilistic programming: www.essentialtechnology.blog/p/the-evolut...

A special opportunity for lovers of mass spectrometry proteomics to join a like-minded team at PTI. Join a collaborative initiative to enable direct protein analysis at unprecedented scale, in partnership with leading instrument developers, academics, and industry leaders. 1/2

So you sequenced a billion+ bases. That don’t impress me much. JERBOA is a toolkit to figure out what genes do at scale. We've used it to unlock 43 non-model microbes across 12 different phyla.

Light-microscopy brain mapping was picked as one of 7 technologies to watch in 2026 by Nature! Hear from E11's CEO @andrewcpayne.bsky.social: www.nature.com/articles/d41...

Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes https://www.biorxiv.org/content/10.1101/2025.11.25.690442v1

It's been an incredibly exciting year in metascience at large, and for us at Convergent. Last week, the NSF announced their Tech Labs Initiative. www.essentialtechnology.blog/p/the-future...

Dim Red Dot Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time. It lies beyond the Affectable Universe. Let me explain… 1/🧵

Last Friday, the @NSF released an RFI for a new Tech Labs Initiative, to "build and scale next-gen independent research organizations to advance science."

A Vision of Metascience; How does the culture of science change and improve? We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science https://pllqt.it/Qg2rOs

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To mark the occasion, FAS CEO Daniel Correa spoke with @sgrodriques.bsky.social and @adammarblestone.bsky.social about how best to run a Tech Lab/FRO-style org, what they've learned, and the role federal funding can play: fas.org/publication/...

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If you've been interested in FROs, you'll want to see this from NSF: sam.gov/opp/7332ade9... "sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."

A genetic platform for a biocementation bacterium https://www.biorxiv.org/content/10.64898/2025.12.05.692644v1

[C]Worthy has secured multi-year support from ORCA and the Patrick J. McGovern Foundation to scale open, trusted science tools for ocean-based carbon removal. We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets. Full announcement: www.cworthy.org/media/cworth...

A global screen for magnetically induced neuronal activity in the pigeon brain www.science.org/doi/10.1126/... - so cool! 🐦🧠

Have a look if you are interested in how the team at @cultivarium.bsky.social is finding electroporation protocols for new microbes: both screening lots of conditions on a custom built electroporator concurrently, and cyclical iteration using bayesian optimization www.biorxiv.org/content/10.1...

Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co. Learn more: evebio.org/pharmome-dat...

Poster now til 12 pm, come check it out at V6! #SfN25

Is there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!

As AI collapses coordination costs, our new thesis - Scaling Trust - explores how scalable trust infrastructure could usher in a world of many AI agents, capable of mobilising, negotiating, and verifying on our behalf across digital + physical spaces ↓ link.aria.org.uk/ST-thesis-BS