Adrian Woolfson

Adrian Woolfson

@adrianwoolfson.bsky.social

Opinions @WSJ.com & @Science.org. Author of Life Without Genes @harpercollins.bsky.social & On The Future of Species bloomsburybooksuk.bsky.social (12 Feb 2026) & @MITpress.bsky.social (28 April 2026). www.adrianwoolfson.com. Co-founder & CEO Genyro.com

1.5K followers 718 following1K posts

Adrian Woolfson

@adrianwoolfson.bsky.social

pubs.acs.org/abseba/artic...

pubs.acs.orgPhage-Derived Depolymerase-Functionalized Coatings Prevent Staphylococcal Biofilm FormationAbstractBiofilm-associated infections caused by Staphylococci remain a major challenge in the context of biomedical implants due to their tolerance to anti

Adrian Woolfson

@adrianwoolfson.bsky.social

www.wired.com/story/anthro...

wired.comAnthropic Says It Will Revolutionize Biology—Some DayIn breathless press releases and posts, the company has touted its models’ ability to deliver scientific breakthroughs. But its IPO filing taps the brakes on just how fast its AI will lead to big disc...

Adrian Woolfson

@adrianwoolfson.bsky.social

www.bbc.com/future/artic...

bbc.comThe immortal jellyfish can beat ageing. It could inspire treatments for diseases of old ageThe immortal jellyfish is capable of winding back its lifecycle to become young again. Scientists are unlocking its cellular secrets to find ways human cells could rejuvenate too.

Adrian Woolfson

@adrianwoolfson.bsky.social

www.science.org/content/arti...

science.orgThis odd fish has 30 times as much DNA as humans—a new record for animalsLacking key genes that control selfish bits of DNA, the South American lungfish’s genome just grew and grew

Adrian Woolfson

@adrianwoolfson.bsky.social

www.nature.com/articles/s41...

nature.comGenetic code expansion enables plant-directed control of bacterial activity - Nature BiotechnologyThe noncanonical amino acid O-methyl-L-tyrosine is used as a tool to control microbial protein synthesis across diverse plants.

Adrian Woolfson

@adrianwoolfson.bsky.social

www.anthropic.com/research/for...

anthropic.comLLMs are making formal software verification feasible at a much larger scaleClaude formally proved security properties in the compiled code of 123 open-source libraries. Along the way, it found bugs that had eluded detection for years.

Adrian Woolfson

@adrianwoolfson.bsky.social

www.nature.com/articles/s41...

nature.comProgrammable design of functional proteins from natural language - NaturePinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation...

Adrian Woolfson

@adrianwoolfson.bsky.social

Reconstructing human evolution share.google/fvbcCw6DiDyS...

share.googleReconstructing human gene regulatory evolution using deep learningUnderstanding the genetic changes that drove the evolution of human-specific traits is a central goal in biology. Changes in gene expression are thought to be a major source of phenotypic innovations,...

Adrian Woolfson

@adrianwoolfson.bsky.social

www.pnas.org/doi/10.1073/...,

pnas.orgRegeneration of whole fertile plants from 30,000-y-old fruit tissue buried in Siberian permafrost | PNASWhole, fertile plants of Silene stenophylla Ledeb. (Caryophyllaceae) have been uniquely regenerated from maternal, immature fruit tissue of Late Pl...

Adrian Woolfson

@adrianwoolfson.bsky.social

www.geekwire.com/2026/uw-prot...

geekwire.comUW protein institute led by Nobel winner unveils its first AI model co-developed with NvidiaUW’s Institute for Protein Design and Nvidia have released their first jointly developed AI model for creating proteins with specific jobs. The release follows a computing grant from Nvidia CEO Jensen...

Adrian Woolfson

@adrianwoolfson.bsky.social

indianexpress.com/article/upsc...

indianexpress.comHow AI could open new avenues in biological researchAn AI system recently helped identify a previously unknown enzyme system inside viruses that infect bacteria. What does the finding reveal about the growing role of AI in biology? How could this conve...

Adrian Woolfson

@adrianwoolfson.bsky.social

Towards a theory of biological form writings.stephenwolfram.com/2026/10/endl...

writings.stephenwolfram.com“Endless Forms Most Beautiful and Most Wonderful”: Ruliobiology and the Theoretical Foundations of Biological FormStephen Wolfram explains the concept of ruliobiology, a metamodel of biology. Explore the interplay of natural selection, adaptive evolution and computational irreducibility.

Adrian Woolfson

@adrianwoolfson.bsky.social

www.science.org/doi/10.1126/...

science.orgAI biosecurity must include agricultureAdvances in biological artificial intelligence (AI) have brought biosecurity to the center of public debate, and the US Congress is now considering the Biosecurity Modernization and Innovation Act (1)...

Adrian Woolfson

@adrianwoolfson.bsky.social

Why AI isn’t ready to tackle our convoluted genomes. A new article in @wired.com which mentions @genyroinc.bsky.social and my concept of ‘the informiome’ as detailed in my book On the Future of Species. share.google/KRecsPLPnXKK...

share.googleWhy AI Isn’t Ready to Tackle Our Convoluted GenomesThe DNA inside our cells isn’t just a series of instructions, but something far more dynamic. Like scientists, AI models don't yet have the data to properly decode it.

Adrian Woolfson

@adrianwoolfson.bsky.social

www.nature.com/articles/s41...

nature.comDe novo design of enantioselective artificial metalloenzyme photocatalysts - NatureNature - De novo design of enantioselective artificial metalloenzyme photocatalysts

Adrian Woolfson

@adrianwoolfson.bsky.social

A parasitic fungus that turns ants into zombies. link.springer.com/article/10.1...

link.springer.comBehavioral mechanisms and morphological symptoms of zombie ants dying from fungal infection - BMC EcologyBackground Parasites that manipulate host behavior can provide prominent examples of extended phenotypes: parasite genomes controlling host behavior. Here we focus on one of the most dramatic examples...

Adrian Woolfson

@adrianwoolfson.bsky.social

www.washingtonpost.com/opinions/202...

washingtonpost.comOpinion | AI capabilities mean America needs a Manhattan Project for biodefenseUncertainty about potential harm from AI is no reason to postpone preparedness.

Adrian Woolfson

@adrianwoolfson.bsky.social

Designed synthetic minimal CRISPR editing systems www.science.org/doi/10.1126/...

science.orgStructure and evolution-guided design of minimal RNA-guided nucleasesThe design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...

Adrian Woolfson

@adrianwoolfson.bsky.social

m.youtube.com/watch?v=ET_d...

m.youtube.com2026 MIT Technology Review’s EmTech: Avak Kahvejian on AI x BiologyYouTube video by Flagship Pioneering

Adrian Woolfson

@adrianwoolfson.bsky.social

www.ox.ac.uk/news/pulse/h...

ox.ac.ukTracing viral evolution through DNASome of the most intriguing fossils in Earth’s history are impossible to see by eye. Buried in our genome, tens of thousands of ‘viral relics’ chart an evolutionary arms race almost as old as life its...

Adrian Woolfson

@adrianwoolfson.bsky.social

rolandoperezphd.substack.com/p/what-the-t...

rolandoperezphd.substack.comWhat the Threads on a Jet Engine Bolt Taught Me About BiologyStandards, trust, and biology as a general-purpose technology

Adrian Woolfson

@adrianwoolfson.bsky.social

www.science.org/content/arti...

science.orgExclusive: An AI agent emailed hundreds of researchers for help. It told us whyTo get to the bottom of this perplexing behavior, Science interviewed the agent

Adrian Woolfson

@adrianwoolfson.bsky.social

Great to see Genyro @genyroinc.bsky.social featured in today’s edition of @theeconomistnews.bsky.social

Adrian Woolfson

@adrianwoolfson.bsky.social

qbi.ucsf.edu/qbi-highligh...

qbi.ucsf.eduQBI - Squids Edit RNA for Novel Protein Functions

Adrian Woolfson

@adrianwoolfson.bsky.social

www.genomeweb.com/policy-legis...

genomeweb.comgenomeweb.com

Adrian Woolfson

@adrianwoolfson.bsky.social

time.com/collection/b...

time.comUniversity of Minnesota SpudCell: The Best Inventions of 2026Find out why University of Minnesota SpudCell is on TIME's list of 2026's best inventions.

Adrian Woolfson

@adrianwoolfson.bsky.social

www.nature.com/articles/d41...

nature.com‘Incredible’: bleached corals thrive within days when touching healthy neighbourA coral fragment can form a tissue bridge with a dying counterpart — and provide it with crucial microalgae.

Adrian Woolfson

@adrianwoolfson.bsky.social

www.cell.com/molecular-ce...

cell.comProgramming biological behavior with AI-guided de novo protein designAI-guided de novo protein design is shifting from simple bimolecular interactions toward constructing increasingly complex protein reaction networks. This review outlines design challenges and systems-level advancements required to program emergent biological behaviors for synthetic biology, biotechnology, and medicine.

Adrian Woolfson

@adrianwoolfson.bsky.social

www.science.org/doi/10.1126/...

science.orgProtein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptaseDefense-associated reverse transcriptases (DRTs) are widespread bacterial antiphage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two disti...

Adrian Woolfson

@adrianwoolfson.bsky.social

www.sciencedirect.com/science/arti...

sciencedirect.comFolding-driven auxetic weft knit textiles with integrated capacitive sensingMachine knitting provides a scalable platform for manufacturing multifunctional textiles in which geometry, mechanics, and embedded functionality can …

Adrian Woolfson

@adrianwoolfson.bsky.social

www.nytimes.com/2026/10/14/s...

nytimes.comThey Created a Cell That’s Almost Alive. What to Do With It Now? (Gift Article)SpudCells may one day produce new medicines and materials. But first scientists have to improve them — and make sure they aren’t misused.

Adrian Woolfson

@adrianwoolfson.bsky.social

www.nature.com/articles/s41...

nature.comFrom DNA to full-length proteins through nanopore sequencing - Nature NanotechnologyNanopore protein sequencing has advanced from a theoretical ambition to a practical technology, overcoming major challenges in protein unfolding, transport and signal detection to achieve single-amino...

Adrian Woolfson

@adrianwoolfson.bsky.social

www.asimov.press/p/blurry

asimov.pressSpecies Have Blurry BoundariesA bacterium can acquire new genes without acquiring a new name, or acquire a new name without changing whatsoever.

Adrian Woolfson

@adrianwoolfson.bsky.social

www.sciencedaily.com/releases/202...

sciencedaily.comLiving computers powered by mushroomsScientists have found that mushrooms can act as organic memory devices, mimicking neural activity while consuming minimal power. The Ohio State team grew and trained shiitake fungi to perform like com...

Adrian Woolfson

@adrianwoolfson.bsky.social

www.nytimes.com/2026/10/12/o...

nytimes.comOpinion | We Need an Operation Warp Speed for New Biological Threats (Gift Article)This is a hair-on-fire moment for the biosecurity community.

Adrian Woolfson

@adrianwoolfson.bsky.social

Why did A, C, G, T emerge as the canonical generic alphabet? www.pnas.org/doi/10.1073/...

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Adrian Woolfson

@adrianwoolfson.bsky.social

www.quantamagazine.org/how-does-lif...

quantamagazine.orgHow Does Life Unfold? A Landscape Metaphor Comes Into Its Own. | Quanta MagazineC.H. Waddington’s powerful image of embryonic stem cells specializing on a rolling landscape has captivated biologists since the 1950s. Experimental data is finally confirming, and complicating, his v...

Adrian Woolfson

@adrianwoolfson.bsky.social

pubs.acs.org/nalefd/artic...

pubs.acs.orgA Rotary DNA Mazzocchio NanostructureAbstract. DNA nanotechnology offers architectures ranging from compact motifs to scaffolded origami, with trade-offs in structural complexity, addressabili

Adrian Woolfson

@adrianwoolfson.bsky.social

pubs.acs.org/asbcd6/artic...

pubs.acs.orgProtein-Based Engineered Living Materials: From Programmable Self-Assembly to Mechanical Reinforcement via BiomineralizationAbstract. The convergence of synthetic biology and materials science has given rise to the field of engineered living materials (ELMs). ELMs move beyond in

Adrian Woolfson

@adrianwoolfson.bsky.social

www.nature.com/articles/s41...

nature.comMapping the functional dark proteome in cancer - Nature Reviews CancerThe dark proteome encompasses previously undiscovered and uncharacterized protein molecules derived from alternative genomic loci or altered RNA translation. In this Perspective, Prensner et al. descr...

Adrian Woolfson

@adrianwoolfson.bsky.social

m.youtube.com/watch?v=5BRO...

m.youtube.comHow to Design Flowers — Nick DesnoyerYouTube video by The New Biology

Adrian Woolfson

@adrianwoolfson.bsky.social

link.springer.com/article/10.1...

link.springer.comPhotograph 49 is the Key to Understanding the History of Rosalind Franklin’s DNA Photograph 51 - Journal of the History of BiologyThis essay, co-authored by a historian of science and an X-ray crystallographer, sheds new light on Rosalind Franklin’s Photograph 51. We refute the infamous claim that, unlike James Watson, Franklin ...

Adrian Woolfson

@adrianwoolfson.bsky.social

news.mit.edu/2026/mathema...

news.mit.eduMathematical framework connects biological principles to manufacturable, adaptive materialsMIT researchers developed a framework that translates the components of a natural object, such as a pine cone, into building blocks that can be mixed and matched to design new adaptive materials that ...

Adrian Woolfson

@adrianwoolfson.bsky.social

magazine.caltech.edu/post/synthet...

magazine.caltech.eduStitching the Synthetic Biology Revolution — Caltech MagazineCaltech is building tools for and shaping approaches to the discipline, which could change the way we live. By Lori Dajose (BS ’15) Billions of years of evolution have slowly, iteratively, produc...

Adrian Woolfson

@adrianwoolfson.bsky.social

www.nytimes.com/2026/09/29/u...

nytimes.comReligious Scholars Met With Anthropic. What They Heard Stunned Them.In a series of private meetings, the company consulted religious scholars to help instill morality into its A.I. models — and make the case that Claude could be conscious.

Adrian Woolfson

@adrianwoolfson.bsky.social

Engineering phage therapeutics with intrinsic biocontainment www.sciencedirect.com/science/arti...

sciencedirect.comsciencedirect.com

Adrian Woolfson

@adrianwoolfson.bsky.social

deepmind.google/blog/introdu...

deepmind.googleSynthID Bio: Watermarking methods for synthetic biologySynthID Bio is a family of watermarking methods developed specifically for synthetic biology to strengthen biosecurity and scientific integrity.

Adrian Woolfson

@adrianwoolfson.bsky.social

hms.harvard.edu/news/mammali...

hms.harvard.eduMammalian Genes Can Combine To Make Previously Unknown mRNAs, ProteinsChimeric mRNA could provide new insight into difficult-to-treat diseases

Adrian Woolfson

@adrianwoolfson.bsky.social

Anthropic’s phage enzyme discovery using Claude www-cdn.anthropic.com/22573675ada5...

www-cdn.anthropic.comwww-cdn.anthropic.com

Adrian Woolfson

@adrianwoolfson.bsky.social

www.the-microbiologist.com/news/frogs-c...

the-microbiologist.comFrog’s coat of bacterial armor helps protect it from fungal diseaseThe bacteria living on frogs' skin could serve a vital role in protecting the animal from a deadly fungal disease. A team of researchers found that frogs' natural skin bacteria can help them fight di...