Angus Bucknell

Angus Bucknell

@ahbucknell.com

PhD candidate in the @talbotlabtsl.bsky.social group. Focusing on protein design and effector biology in Magnaporthe oryzae. www.ahbucknell.com

284 followers273 following60 posts

Angus Bucknell reposted

Excited to share this bioRxiv where we identify another host target for a Magnaporthe effector. Here we characterise the interaction between the zinc finger fold effector (Tie1) to a conserved family of transcription factors called the Tubby-like F-box proteins (TLPs) www.biorxiv.org/content/10.6...

biorxiv.orgA Blast Fungus Effector Targets a Tubby-like F-box Protein to Suppress Plant ImmunityThe blast fungus Magnaporthe oryzae is one of the most destructive pathogens of rice, secreting effector proteins that reprogram host cells to enable infection. Identifying plant targets of these fung...

Angus Bucknell reposted

🚨 Please share! 🚨 I'm recruiting a fully funded 4-year Gatsby Sainsbury PhD studentship at Durham! 🌱🤖 Designing plant immune receptors from scratch, combining AI protein design with structural biology and plant immunity. If you're interested please get in touch! benthamlab.org shorturl.at/U2PdV

benthamlab.orgBentham Lab — Durham UniversityBentham Lab, Centre for Programmable Biological Matter, Durham University. Structural biology and de novo protein design applied to host-pathogen interactions, plant immunity, and neglected tropical d...

This was a really fun event! I really enjoyed seeing the transitions from research to product. It was nice to have a good turnout of research there from @thesainsburylab.bsky.social.

The Sainsbury Laboratory@thesainsburylab.bsky.social

TSL's research & Ventures proudly represented at at the Norwich Research Park Poster Showcase Event. Molecular insights into plant-microbe interactions hold major biotech potential - in agriculture AND therapeutics. Thanks to AIP for the opportunity to spark valuable discussions with industry ✨️

I've really enjoyed having Adam as a supervisor for my PhD @thesainsburylab.bsky.social. Would definitely recommend a PhD with him, this is some really cutting-edge science in a great lab!

Adam Bentham@adamrbentham.bsky.social

🚨 Please share! 🚨 I'm recruiting a fully funded 4-year Gatsby Sainsbury PhD studentship at Durham! 🌱🤖 Designing plant immune receptors from scratch, combining AI protein design with structural biology and plant immunity. If you're interested please get in touch! benthamlab.org shorturl.at/U2PdV

Angus Bucknell reposted

Angus Bucknell reposted

Angus Bucknell reposted

See thread by @metalichen.bsky.social on Tangerine - A Starship in the genomes of lichen-forming fungi - the peer-reviewed version is now online. Thanks to all co-authors. It's been a fun collaboration and there's lots more to discover!👇

Gulnara Tagirdzhanova@metalichen.bsky.social

Our study on giant transposons Starship 🚀🧬 in the genome of the lichen fungus Xanthoria is now out in @pnas.org! What did we find out about Starships in #lichen fungi? 👇Updated thread below 🖥️ 🧪 🦠 🧫 #SymbioSky 1/6 www.pnas.org/doi/10.1073/...

Angus Bucknell reposted

Angus Bucknell reposted

Excited to see our new preprint on bioRxiv! 🌱🤖 We used AI protein design (RFdiffusion + ProteinMPNN) to build brand-new sensor domains from scratch and installed them in a rice NLR immune receptor engineering recognition of a Fusarium effector FoSSP17

yuxuan-xi.bsky.social@yuxuan-xi.bsky.social

Our new preprint is out! Using AI-guided design (RFdiffusion + ProteinMPNN), we engineered a plant immune receptor to recognise non-cognate pathogen effectors. Huge thanks to our amazing co-authors for making this possible! doi.org/10.64898/202...

Angus Bucknell reposted

This has been a great project to work on and I’m very excited to see where this technology is headed within plant pathology. Big thanks to all the contributors, especially @yuxuan-xi.bsky.social and @adamrbentham.bsky.social!

yuxuan-xi.bsky.social@yuxuan-xi.bsky.social

Our new preprint is out! Using AI-guided design (RFdiffusion + ProteinMPNN), we engineered a plant immune receptor to recognise non-cognate pathogen effectors. Huge thanks to our amazing co-authors for making this possible! doi.org/10.64898/202...

Angus Bucknell reposted

Angus Bucknell reposted

Our first invited speaker of the #NRPDTP26 conference is Dr Marco Catoni, from the University of Birmingham. Today he’s talking about combining genomics and plant grafting to investigate mobile RNAs.

Angus Bucknell reposted

So proud to see this story finally out!🎉 We added new data since our previous preprint—transgenic barley plants with an engineered immune receptor that fights off two fungal pathogens at once. Short 🧵 and link to the original preprint thread on X👇 www.science.org/doi/10.1126/...

science.orgMolecular mimicry of a pathogen virulence target by a plant immune receptorPlants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...

A great day of talks and posters - looking forward to tomorrow. Especially @metalichen.bsky.social’s talk! #Mendel_ECR_26

Day 1 of the Mendel Early Career Symposium! 100 international researchers gathered for networking, engaging talks & posters, keynote by @emmanuellebayer.bsky.social, & workshop on ChimeraX/AlphaFold. Thanks to the sponsors for supporting expanding horizons in #PlantBiology. #Mendel_ECR_26

Angus Bucknell reposted

Césarée Morier-Gxoyiya @cesaree-mg.bsky.social asks what is causing the rise of wheat 🌾 stem rust? Is the rising temperature 🥵 in the UK to blame for this increase? Unlikes the rusts, Césarée will end this cycle (aka her PhD) looking for a postdoc #fungal26

Angus Bucknell reposted

Starships in fungi are so intriguing & have clearly had enormous (& diverse) impacts on genome evolution. @mycomile.bsky.social So many questions- the catalytic mechanism of YR Captains, target-site selection, how they move between fungi? (anastomosis/ role for parasexuality?) Amazing #Fungal26

Angus Bucknell reposted

Want to hear about gene regulation driving pathogenicity in the rice blast fungus? Come to my talk this afternoon at the Cell Wall Synthesis and Remodelling session at 16:40! Or my poster tonight! 🍄 #Fungal26

I’ll be talking today at the #Fungal26 concurrent session: AI in Fungal Research. I’ll be presenting on protein design in M. oryzae at 15:20 in the Fred Farr Forum. I’ll also be presenting my poster (#651A) tonight - come say hi!

Angus Bucknell reposted

Here is our very own 'PhosphoJave' Bautista introducing his family of phosphorylated fungal effectors and their potential regulation #Magnafest26 #Fungal26