Alexey Amunts

Remarkable study @nature.com @jeremiahycohen.bsky.social @alleninstitute.org noradrenergic neurons in the mouse locus coeruleus project to different targets and exhibit distinct activity patterns during learning, linked to gene expression and cell position. www.nature.com/articles/s41...

Congratulations to Yingying Hu & Zhiwen Ye on starting labs at SMART! Yinying did a postdoc at UT Southwestern and her lab is working on embryonic development. Zhiwen did postdocs at @crick.ac.uk and University of Washington, and he is system neuroscientist working on brain sensorimotor integration.

www.cell.com/cell/fulltex...

0.43 Å. The highest resolution protein structure determined. Archaeal rubredoxin protein structure bridging the gap between structural biology and quantum chemistry.

RNA can build. A short RNA self-assembles into a 60-subunit icosahedral cage like a viral capsid, but made entirely of RNA. The striking preprint also reveals a 57-nt RNA filament at ~2.7 Å. Congratulations, Lin Huang and colleagues! www.biorxiv.org/content/10.6...

Sad news about the sudden passing of Richard Neutze. A friend and pioneer of time resolved studies. His bold work on intermediates inspired many of us. His enthusiasm helped shape MAX IV in Sweden and generations of scientists all over the world. We'll miss the warm smile, curiosity and generosity.

Fascinating new @nature.com paper: a Pluto moment for biology. It introduces the concept of 'peptideins' - a new category for dark translated ORFs that produce detectable microprotein-like products with unknown biological roles.

The first Max Planck Center in Shenzhen. @maxplanck.de and Chinese Academy of Sciences launch a Center for Synthetic Biochemistry at Shenzhen Institute of Advanced Technology. It will leverage automated infrastructure for biomanufacturing of natural products. Germany-China partnership is growing.

Since our preprint on the ETC-ATP synthase supercomplex has attracted attention, I would like to introduce the platform we used, Langtaosha. It was launched by SMART together with several other institutions with support from Open Life Science Alliance, aiming for long-term open infrastructure 1/4

So, overall, it will incorporate new technologies, and provide long term support and timely response to the growing needs of the international research community for science exchange 3/4

Since our preprint on the ETC-ATP synthase supercomplex has attracted attention, I would like to introduce the platform we used, Langtaosha. It was launched by SMART together with several other institutions with support from Open Life Science Alliance, aiming for long-term open infrastructure 1/4

In a followup with @longzhou88.bsky.social and Yue Liu we move from molecular mechanism to membrane architecture. A giant ETC-ATP synthase assembly containing 10 ATP synthases and 6 respiratory complexes builds long-range periodic OXPHOS arrays on native cristae langtaosha.org.cn/lts/en/prepr... 1/4

High-res cryo-EM structures of different pieces from such long-range array in Leishmania provide details of the interfaces involved. The findings validate the single particle prequel and shed light on the divergent bioenergetic and cristae shaping strategies employed by different discobids. 3/4

In a followup with @longzhou88.bsky.social and Yue Liu we move from molecular mechanism to membrane architecture. A giant ETC-ATP synthase assembly containing 10 ATP synthases and 6 respiratory complexes builds long-range periodic OXPHOS arrays on native cristae langtaosha.org.cn/lts/en/prepr... 1/4

65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵

Evolutionary analysis by Martijn Huynen further suggests that this architecture emerged in lineages where canonical complex I was lost or extensively modified, pointing to a new solution for spatial organization of oxidative phosphorylation 5/6

65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵

Atomistic simulations by Vivek Sharma, showed induction of a shallow positive membrane curvature. By contrast, CIICIV₂ assembly lacking ATP synthase relaxed toward a flatter membrane conformation, suggesting that stable curvature is specifically sustained by incorporation of ATP synthase 3/6

65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵