Andreas Ingham

Andreas Ingham

@andreasingham.bsky.social

Postdoctoral researcher at the Mailand lab. Interested in histone transcription, but also follow any climbing-related content

195 followers610 following4 posts

Andreas Ingham reposted

Nature Structural & Molecular Biology
@natsmb.nature.com

New online: A proteome-wide dependency map of protein interaction motifs

dlvr.itA proteome-wide dependency map of protein interaction motifsNature Structural & Molecular Biology, Published online: 06 March 2026; doi:10.1038/s41594-026-01762-2Ambjรธrn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using base-editing screens, identifying 450 reported and 264 predicted SLiMs required for normal cell proliferation.

Andreas Ingham reposted

Anja Groth
@groth-anja.bsky.social

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org ๐Ÿ™Œ Happy we could contribute. See ๐Ÿ‘‡

Susi Bantele@sbantele.bsky.social

๐—–๐—ฎ๐—ป ๐—ฐ๐—ฒ๐—น๐—น๐˜€ ๐—ฒ๐˜ƒ๐—ฒ๐—ฟ ๐˜๐—ฟ๐˜‚๐—น๐˜† ๐—ฟ๐—ฒ๐—ฐ๐—ผ๐˜ƒ๐—ฒ๐—ฟ ๐—ณ๐—ฟ๐—ผ๐—บ ๐——๐—ก๐—” ๐—ฑ๐—ฎ๐—บ๐—ฎ๐—ด๐—ฒ?Excited to share our new study โ€œRepair of DNA double-strand breaks leaves heritable impairment to genome functionโ€, revealing DNA repairโ€™s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.๐Ÿงต๐Ÿ‘‡1/n

tinyurl.comRepair of DNA double-strand breaks leaves heritable impairment to genome functionUpon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...

Andreas Ingham reposted

Andrew Blackford
@andrewblackford.bsky.social

Excited to share our labโ€™s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1โ€“CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

biorxiv.orgDDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosisDNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

Andreas Ingham reposted

Duxin lab
@duxinlab.bsky.social

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

Andreas Ingham
@andreasingham.bsky.social

Linker histone expression is uniquely controlled by a specific pathway, which can be manipulated to increase TOP2i sensitivity! Proud to share first authorship on our story now out in @cp-molcell.bsky.social. www.cell.com/molecular-ce...

cell.comCRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor toleranceIngham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP...

Andreas Ingham reposted

Molecular Cell
@cp-molcell.bsky.social

Online Now: CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance Online now:

dlvr.itCRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor toleranceIngham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP1-dependent H1 synthesis induces excessive demand for topoisomerase II activity in low-accessibility chromatin states, thereby increasing sensitivity to TOP2 inhibitors.

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