Christopher A. Baker

Christopher A. Baker

@bakermind.bsky.social

Firstgen Scientist in Yale Center for Infection and Immunity using imaging and transcriptomic technologies to alleviate pain in long COVID and similar syndromes.

331 followers223 following405 posts

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The sensors transmitting information that we interpret as pain are throughout our body and reach into the outermost layers of the skin (visualized here in magenta in a transgenic mouse's toe under a two-photon microscope). Pain is a major symptom of long COVID and other chronic syndromes

Completely moved to hear the emotion in your voice, @profgalloway.com, regarding alleged abuse of Belgian Malinois and prisoners. The notion that anyone could abuse the bond of a Malinois to perpetuate heinous acts is disgusting. They will die for you. Mine is one of the best things to happen to me

Looking back at the setlist, it was killer. Help->Slipknot!->Franklin's New Minglewood Blues Easy to Love You Peggy-O Masterpiece Brown Eyed Women Cassidy Deal China Cat Sunflower I Know You Rider Looks Like Rain Terrapin Station drums The Other One Morning Dew The Weight

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Some disagree: one of my mentors warned against spending too much effort to disprove flawed assertions. Gotta light a candle, perhaps. Kidd not only cleaned up the literature but made seminal contributions (importance of considering diversity in genetic studies, ironically) 3/

Importantly, Kidd et al. IMPROVED the field and led to real genetic causes of autism or psychiatric disorders. But there are certainly environmental causes of childhood psychiatric disorders too. So the goal (hopefully) is not to necessarily disprove, but instead to IMPROVE 4/4

It's common for a field to develop "trendy" topics (I'm old enough to remember nNOS) and also trendy to tear down trendy topics. Such criticism is still important (e.g. Ken Kidd helped a lot by removing spurious genetic association studies in psychiatric disease) 2/

intersection of SARS-CoV-2 and beta amyloid gets at concepts that have bugged me for years: 1) that amyloid deposition is an antecedent of infection or host defense, and 2) that spike protein itself may have amyloidogenic properties. science.org/doi/epdf/10....

science.orgSARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoidsYou have to enable JavaScript in your browser's settings in order to use the eReader.

This paper is suggestive but not conclusive - it shows that dumping spike protein on human retina cultures induces beta amyloid that colocalizes with spike, and that similar colocalization is detected in postmortem retina from COVID patients. Very thought-provoking nevertheless

I made a post earlier about Fluorescence Friday, but some people say it's Fascist Friday because of the ouster of UVA president... to which I say I'm still going to do science for the public interest for as long as I can

People consider the pineal gland to be a Third Eye. Maybe they should have focused on the Subfornical Organ instead - also in the middle of the brain, but with a newly acknowledged pathway for T cell traffic between the gut and the brain that affects behavior #FluorescenceFriday

above we see the Subfornical Organ dangling into the 3rd ventricle of the brain, flanked by choroid plexus cells making cerebrospinal fluid. Cell nuclei in blue, with in situ hybridization for genes marking macrophage subsets: F13a1 (yellow), Cx3cr1 (magenta), and Aif1 (cyan)

Christopher A. Baker reposted

@karaswisher.bsky.social I'm dying for you and Scott to address the gutting of science (and academics in general) under this administration on @pivotpod.bsky.social. You can discuss all tech and economic activity generated by NIH not to mention the novel therapeutics www.science.org/content/arti...

science.orgSaying ‘pandemic is over,’ NIH starts cutting COVID-19 researchGrant terminations halt research on improving vaccinations and preventing future pandemics

Looks like climate is definitely on the chopping block. So much for RFK saying he was an advocate for environmental causes of chronic illness. I think it only matters if the causes are certain ones. Deepest sorrow and condolences

Kelton Minor@keltonminor.bsky.social

How is the government (& possibly DOGE) targeting which grants to cut? Which AI prompts + keywords are they using, where is the transparency & oversight? Decisions for which grants to cut didn’t come from NIH program officers who manage the grants, but from higher up 8/

Mouse midline cerebral cortex, including the anterior cingulate area, motor cortex, and somatosensory cortex. Nuclei in blue and myelin tracts in green. Magenta staining for the c-Fos immediate-early gene as a proxy for sustained neuronal activity. #FluorescenceFriday

Christopher A. Baker reposted

IMO the purpose of peer review is to improve the scientific literature. Suggest experiments to bolster conclusions, or qualifying statements that acknowledge limitations of the study. Reject if these actions cannot bring the paper to the standard of the journal in question

Dr. Becca@docbecca.bsky.social

I am somehow for the first time ever reviewing for PNAS and their reviewer instructions include this BANGER of a line: "The purpose of peer review is not to demonstrate proficiency in identifying flaws" Print it in eleventy point font and hang it from the hillside. Scream it from the rooftops.