Barbara Marte (@barbmarte.bsky.social)

Barbara Marte

@barbmarte.bsky.social

Senior Editor @Nature for cancer and cell cycle. Views my own

5.4K followers 954 following225 posts

Barbara Marte

@barbmarte.bsky.social

new out in @nature www.nature.com/articles/s41...

nature.comWEE1 opposes APC/CCDH1 activity to promote S phase entry - NatureExperimental and modelling data indicate that WEE1 promotes re-entry of quiescent cells into the cell cycle, potentially explaining the toxic side effects of WEE1 inhibitors in cancer therapies.

Barbara Marte

@barbmarte.bsky.social

new out in @nature www.nature.com/articles/s41...

nature.comDivergent genomic evolution in astrocytomas and oligodendrogliomas - NatureLongitudinal genomic analyses in patients with astrocytoma or oligodendrioglioma suggest that these two types of tumour differ in the mechanisms by which they become resistant to treatment, with astro...

Barbara Marte

@barbmarte.bsky.social

new out in @nature www.nature.com/articles/s41...

nature.comtRNA dosage regulates lineage dependency and resistance in prostate cancer - NatureA tRNA-specific regulatory pathway is associated with codon biology, lineage transitions and therapy resistance in prostate cancer.

Barbara Marte

@barbmarte.bsky.social

new out in @nature www.nature.com/articles/s41...

nature.comA preinvasive regulatory T cell axis for lung cancer interception - NatureAn effector regulatory T cell circuit is identified that can be monitored in blood samples to track the development of lung cancer, and blockade of this immune network in the preinvasive setting ...

Barbara Marte

@barbmarte.bsky.social

23 Sept

new out in Nature www.nature.com/articles/s41...

nature.comTargeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion - NatureZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its deletion boosts effector-lik...

Barbara Marte

@barbmarte.bsky.social

23 Sept

new out in Nature www.nature.com/articles/s41...

nature.comA design approach for bitopic kinase inhibitors - NatureDetailed analyses of ligand choice, linkage vector and linker length enabled the development of bitopic inhibitors of ABL1 and EGFR kinases, including an ABL1 inhibitor with enhanced activity aga...

Barbara Marte

@barbmarte.bsky.social

23 Sept

new out in Nature www.nature.com/articles/s41...

nature.comHepatocytes promote liver metastasis of pancreatic cancer by providing serine - NatureMetastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this amino acid, thus promoting tumour growth a...

Barbara Marte

@barbmarte.bsky.social

17 Sept

new out in @nature www.nature.com/articles/s41...

nature.comIdentification of broadly tumour-reactive γδ TCRs from multiple myeloma - NatureA machine-learning algorithm, PreGame, is developed to identify tumour-reactive γδ T cells from single-cell CITE sequencing data, and expansion of this cell population can be used as a biomarker of th...

Barbara Marte

@barbmarte.bsky.social

17 Sept

new out in @nature www.nature.com/articles/s41...

nature.comEvolution and heterogeneity of lethal metastatic bladder cancer subtypes - NatureA rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of aggressive histological subtypes and therapy resistance in metastat...

Barbara Marte reposted

Shom Goel

@shomgoel.bsky.social

7 Sept

A nice follow-up to our recent @nature.com paper (@barbmarte.bsky.social). Nature has published a News & Views piece discussing the work: “The secret life of a cell-cycle gatekeeper of cancer.” Very proud of the team. Interested to hear where these concepts go next. www.nature.com/articles/d41...

nature.comThe secret life of a cell-cycle gatekeeper of breast cancerA newly discovered function for the protein Rb explains why inhibiting cell division can enhance the signalling mediated by the oestrogen receptor that drives breast cancer.

Barbara Marte

@barbmarte.bsky.social

3 Sept

and the Clinical Briefing to go with it www.nature.com/articles/d41...

nature.comBiomarkers that predict improved outcomes after perioperative immune-based therapy for lung cancerPre-surgical clearance of circulating tumour DNA was associated with benefits when using the immunotherapy nivolumab.

Barbara Marte

@barbmarte.bsky.social

3 Sept

new out in @nature www.nature.com/articles/s41...

nature.comBiomarkers of nivolumab benefit in resectable non-small cell lung cancer - NaturePotential predictive biomarkers of perioperative nivolumab therapy benefit in non-small cell lung cancer are identified from evaluable participants in the CheckMate 77T trial.

Barbara Marte

@barbmarte.bsky.social

19 Aug

new our in @nature www.nature.com/articles/s41...

nature.comFunctional role of skull lymphoid structures in CNS immunosurveillance - NatureFunctional lymphoid structures within the skull bone marrow enable central nervous system immunosurveillance and shape immune responses to brain disease.

Barbara Marte

@barbmarte.bsky.social

13 Aug

new out in @nature www.nature.com/articles/s41...

Barbara Marte

@barbmarte.bsky.social

13 Aug

new out in @nature www.nature.com/articles/s41...

nature.comIn vivo genome-wide CRISPR screens of human T cells in solid tumours - NatureAn in vivo model that is able to recover human T cells from solid tumours can identify targets to help improve CAR T cell antitumour activity.

Barbara Marte

@barbmarte.bsky.social

13 Aug

new out in @nature www.nature.com/articles/s41...

Barbara Marte

@barbmarte.bsky.social

6 Aug

new out in @nature www.nature.com/articles/s41...

nature.comMembranolytic peptide programs immunogenic cell death for cancer therapy - NatureThe synthetic-acid-responsive membranolytic peptide aMPC16-CA50 induces immunogenic membranolytic cell death in tumour cells, robustly potentiating immune checkpoint blockade therapy.

Barbara Marte

@barbmarte.bsky.social

6 Aug

new out in @nature www.nature.com/articles/s41...

nature.comA tumour-derived organoid biobank maps cancer gene dependencies - NatureA clinically annotated multi-omic organoid resource with matched tumour samples from 256 patients across 5 cancers maps gene dependencies, reveals subtype-specific vulnerabilities and uncovers treatme...

Barbara Marte

@barbmarte.bsky.social

6 Aug

new out in @nature www.nature.com/articles/s41...

nature.comA compendium of next-generation patient-derived models for diverse cancers - NatureThe international collaboration of the Human Cancer Models Initiative presents a comprehensive resource of next-generation cancer models from 2,780 donors with 25 cancer types and integrated tumour–mo...

Barbara Marte

@barbmarte.bsky.social

6 Aug

new out in @nature www.nature.com/articles/s41...

nature.comA dependency map enhanced with next-generation 3D cancer models - NatureIntegration of genome-scale CRISPR screening data from traditional cell lines and next-generation cancer models expands the representation of tumour subtypes and genomic alterations in The Cancer Depe...

Barbara Marte

@barbmarte.bsky.social

6 Aug

new out in Nature www.nature.com/articles/s41...

nature.comZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer - NatureThe RNA-binding protein ZFP36L2 mediates stress-adaptive plasticity in intestinal regeneration and colorectal cancer metastasis.

Barbara Marte

@barbmarte.bsky.social

30 July

and the News & Views www.nature.com/articles/d41...

nature.comIntestinal stem cells count to eight divisions to maintain cell ratiosIn the fly gut, stem cells keep the balance of cell types by undergoing eight rounds of cell division to form absorptive cells, then one round to form secretory cells.

Barbara Marte

@barbmarte.bsky.social

30 July

new out in Nature www.nature.com/articles/s41...

nature.comIntestinal stem cells count self-renewal divisions to switch multipotency - NatureIn Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

Barbara Marte

@barbmarte.bsky.social

22 July

new out in Nature www.nature.com/articles/s41...

nature.comGenetic background sets the trajectory of experimental cancer evolution - NatureExperimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

Barbara Marte

@barbmarte.bsky.social

22 July

new out in Nature www.nature.com/articles/s41...

nature.comTertiary lymphoid structures harbour stem-like tumour-specific T cells - NatureRenal cell carcinoma tumours containing tertiary lymphoid structures (TLSs) are enriched for exhausted CD8+ T cells, including tumour-specific clonotypes with stem-like progenitor features and reduced...

Barbara Marte

@barbmarte.bsky.social

22 July

new our in Nature www.nature.com/articles/s41...

nature.comPrior therapy defines mutation profiles in childhood cancer at relapse - NatureChemotherapy, particularly with platinum-based drugs, is associated with substantial, rapidly detectable mutagenesis in childhood cancers, tripling private signatures and doubling mutation burden, hig...

Barbara Marte

@barbmarte.bsky.social

22 July

and our News story www.nature.com/articles/d41...

nature.comRare contagious cancer discovered in wild catfishTransmissible tumours have been found in only a few types of animal, but there might be many more out there.

Barbara Marte

@barbmarte.bsky.social

22 July

new out in Nature www.nature.com/articles/s41...

nature.comBrown bullhead catfish melanoma represents a novel transmissible cancer - NatureWhole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

Barbara Marte

@barbmarte.bsky.social

16 July

new out in @nature.com www.nature.com/articles/s41...

nature.comGPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma - NatureChimeric antigen receptor (CAR) T cells for antitumour therapy ‘armoured’ with a dominant-negative TGFβ receptor II show enhanced efficacy and tolerable safety in patients with advanced...

Barbara Marte

@barbmarte.bsky.social

16 July

new out in @nature www.nature.com/articles/s41...

nature.comModular in vivo antibody–ADC click to reverse drug resistance in tumours - NatureIn vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant ...

Barbara Marte

@barbmarte.bsky.social

16 July

and the News & Views to go with www.nature.com/articles/d41...

nature.comA high-fat, low-carbohydrate diet can feed intestinal tumoursA ketogenic diet promotes tumour growth in the small intestine in susceptible mice. In people, diet advice might need to be tailored to individual cancer risks.

Barbara Marte

@barbmarte.bsky.social

16 July

new out in @nature www.nature.com/articles/s41...

nature.comKetogenic diet mediates intestinal tumorigenesis through lipids not ketones - NatureA combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in ketoge...

Barbara Marte

@barbmarte.bsky.social

9 July

new out in Nature www.nature.com/articles/s41...

nature.comDiet–microbiome synergy underlies obesity-associated immunotherapy efficacy - NatureDiet shapes obesity-associated therapeutic responses to immune checkpoint inhibitors through gut microbial metabolism and host anti-tumour immunity, demonstrated in mouse custom-diet models&...

Barbara Marte

@barbmarte.bsky.social

9 July

new out in Nature www.nature.com/articles/s41...

nature.comChromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia - NatureAn ATAC-seq-based approach is used to classify acute myeloid leukaemia (AML) into 16 epigenomic subgroups, and provides insight into the role of non-genetic mechanisms in determining pathogenesis, cli...

Barbara Marte

@barbmarte.bsky.social

8 July

new out in Nature www.nature.com/articles/s41...

nature.comAneuploidy selects for the acquisition of driver genes in breast cancer - NatureScreening of chromosome arm-level aneuploidies uncovers that these alterations select for specific basal-like breast cancer driver genes, including PLGRKT, an oncogene whose tumour-promoting activity ...

Barbara Marte

@barbmarte.bsky.social

1 July

new out in Nature www.nature.com/articles/s41...

nature.comCasdatifan shows durable response linked to HIF-2α biology in kidney cancer - NatureMonotherapy with the HIF-2α inhibitor casdatifan achieves meaningful, durable responses linked to HIF-2α biology with manageable safety in the treatment of individuals with clear cell renal cell ...

Barbara Marte

@barbmarte.bsky.social

1 July

new out in Nature www.nature.com/articles/s41...

nature.comDual tumour–myeloid targeting of glioblastoma with GPNMB CAR-T cells - NatureIntegrated multi-omic profiling of glioblastoma reveals GPNMB as a shared antigen in tumour cells and the surrounding microenvironment, and GPNMB-targeted chimeric antigen receptor T cells demonstrate...

Barbara Marte

@barbmarte.bsky.social

1 July

and the associated Research Briefing www.nature.com/articles/d41...

nature.comLiver fat steers the outcome of advanced colorectal cancerIndividuals with fatty-liver diseases have a heightened risk of aggressive secondary tumours in colorectal cancer.

Barbara Marte

@barbmarte.bsky.social

1 July

new out in Nature www.nature.com/articles/s41...

nature.comSteatosis shapes prognosis-defining liver metastasis heterogeneity in CRC - NatureLiver steatosis increases formation of replacement liver metastases by increasing MYC stability through acetylation, which increases proline synthesis and collagen production.

Barbara Marte

@barbmarte.bsky.social

12 June

new out in Nature this week www.nature.com/articles/s41...

nature.comA prognostic human brain network for diffuse midline glioma - NatureTumour network mapping of diffuse midline glioma (DMG) defines a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherw...

Barbara Marte

@barbmarte.bsky.social

28 May

new out in Nature www.nature.com/articles/s41...

nature.comαKG-mediated carnitine synthesis drives DNA repair via histone acetylation - NatureThe metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

Barbara Marte

@barbmarte.bsky.social

21 May

new out in Nature www.nature.com/articles/s41...

nature.comMitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Naturel-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...

Barbara Marte

@barbmarte.bsky.social

14 May

new out in Nature www.nature.com/articles/s41...

nature.comEcotypes of triple-negative breast cancer in response to chemotherapy - NatureTreatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA expression and cell cycle activity that are asso...

Barbara Marte

@barbmarte.bsky.social

7 May

new out in Nature www.nature.com/articles/s41...

nature.comNon-invasive profiling of the tumour microenvironment with spatial ecotypes - NatureMultimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via ...

Barbara Marte

@barbmarte.bsky.social

7 May

New out in Nature, a Perspective some 20 years after the original studies in Nature showing synthetic lethality between BRCA mutations and PARP inhibition www.nature.com/articles/s41...