Baylink Lab

Baylink Lab

@baylinklab.bsky.social

🦠Enthusiastic microthanatologists (i.e. the study of how to kill microbes) & lovers of redox biology and bacterial chemotaxis🧫 Washington State University - Esch LEAD Professor - Inclusion of Rural Individuals in Science (IRIS) www.baylink-lab.com

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Call for manuscripts on bacterial chemotaxis and swimming! I'm partnering with JoVE to assemble a new collection of method, reviews, and research. ➡️Abstracts due Nov. 23rd. I invite you to share your love (and knowledge) of swimming bacteria! www.jove.com/topical-coll... 🧪 🦠 🧫 #microsky

The video shows our Chemosensory Injection Rig Assay (CIRA) with atmospheric control. Salmonella Typhimurium cultured at 1% O₂ swim toward an injected source of 21% O₂ over 5 min. Study led by Kailie Franco, and big thanks to contributions from Clara Shin, Kendal Cooper, and Olivia Steele-Mortimer.

Lots of great vector-borne disease research in our department here at #WSU in Pullman, WA. Come join the team! Borrelia, Anaplasma, and more! Veterinary Microbiology & Pathology Dept within the College of Veterinary Medicine. #lymedisease #microsky #idsky 🧪🦠🧫

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12+ years & multiple generations of scientists. We are excited to share a new preprint describing structure(s) of H. pylori transducer-like protein D (TlpD), a key chemotaxis protein and a model for a widespread class of soluble chemoreceptors. ▶️ Preprint: lnkd.in/gUw67dU8 🦠 🧪 #microsky #idsky

A big congratulations to future #IDsky physician-scientist Bruce Redden for his research presentation award at this year's ABRCMS. Lots of time and practice went into that presentation! Such a great meeting for the next generation of researchers to network & share discoveries! 🦠🧪 #medsky #medsky

ASM NW was wonderful this year! In addition to the great science, this trainee-focused meeting plays such an important role in providing the next generation of scientists, microbiologists, and clinicians an opportunity to learn, network, and share their own research. 🧪🦠

You’ve heard of #Lymedisease, but have you ever seen the bacteria that causes it? 🦠 Borrelia burgdorferi, the spiral-shaped culprit transmitted by ticks, swims with a creepy wriggling motion and uses #chemotaxis to navigate. Both fascinating... and disgusting #Microsky 🧪 #IDsky @shawlab.bsky.social

You’ve heard of #Lymedisease, but have you ever seen the bacteria that causes it? 🦠 Borrelia burgdorferi, the spiral-shaped culprit transmitted by ticks, swims with a creepy wriggling motion and uses #chemotaxis to navigate. Both fascinating... and disgusting #Microsky 🧪 #IDsky @shawlab.bsky.social

🚨 Postdoctoral Position 🚨 Investigate molecular mechanisms of protein homeostasis in Salmonella during infection! Strong background in biochemistry/molecular biology encouraged. 📩 Send CV, publications, and statement to Eduardo A. Groisman at Yale: eduardo.groisman@yale.edu 🧪 #microsky 🦠 #BLAST

Wonderful how Alphafold has opened up protein structure prediction to non-experts but you still have to feed it correct information (like oligomeric state!). A small test case shows AF3 makes excellent guesses on natural variants but inaccuracies occur from dubious user inputs. #microsky #IDsky 🧪🦠

Lots of new-to-protein-structure folks are using AF3, which is great! However, non-experts might be inclined to feed AF3 incorrect information, such as modeling a monomer when the biologically-relevant state is a dimer. We found this can decrease model accuracy due to missing tertiary interactions.

Wonderful how Alphafold has opened up protein structure prediction to non-experts but you still have to feed it correct information (like oligomeric state!). A small test case shows AF3 makes excellent guesses on natural variants but inaccuracies occur from dubious user inputs. #microsky #IDsky 🧪🦠

Antibiotic resistance and immunogenicity are impacted by small variations in protein sequence but it isn't feasible to experimentally determine structures for the many thousands of variants that exist in nature. In this particular system AF3 generated extremely accurate models for variant sites.

Baylink Lab reposted

🚨 2 funded #PhD positions (ERC Adv Grant) in the Moissl-Eichinger Lab, Graz! Study Methanobrevibacter as a keystone in the gut microbiome. 💡 Omics, modeling, synthetic consortia 📅 Deadline: Sept 10, 2025 🌍 Int’l applicants welcome! Application link below. #microbiomesky #archaeasky #microsky

Some behind-the-scenes insight on the research for non-experts. And FYI, the 'stinky' indole for poo we studied here is actually a major ingredient in lots of perfumes. Turns out it smells better at low concentrations! news.wsu.edu/press-releas...

news.wsu.eduDisease-causing bacteria can deal with stink as long as they get a mealNew WSU research shows gut pathogens like Salmonella will brave a toxic chemical to reach nutrients, offering insights for treating infections.

🚨 Postdoc Opportunity – Rutgers University! Join Ann Stock’s lab to study how Bacteroides regulate fiber and glycan metabolism via hybrid two-component systems. Structural + regulatory biology | CryoEM, crystallography, gene regulation 🔗 Apply | 🔬 Lab 📧 stock@cabm.rutgers.edu #postdoc #microsky 🧪🦠

And this also biases the directions and priorities of science in ways that don’t necessarily reflect the values of the broader public.

Dr Craig R McClain@drcraigmc.bsky.social

Behind many scientists is a lifetime of invisible, unsustainable costs. From unpaid internships to underpaid postdocs, the economic toll of a STEM career is staggering—and it's pushing talent out. My new perspective explores this crisis. #STEM #AcademicBlueSky journals.plos.org/plosbiology/...

The video shows 5 minutes of S. Typhimurium IR715 responding through chemotaxis to a mixture of chemical effectors present in human feces at fecal-relevant concentrations. This image shows max projections of the start and end points across different mixtures, showing how indole regulates attraction.

🧪 #microsky 🧫🦠

BLAST Meetings@blastmeetings.bsky.social

New in Nature Microbiology! Some bacteria sacrifice their own biomass to keep swimming for days during carbon starvation, while others play it safe and conserve resources. Survival strategies in motion! 🚀🦠 www.nature.com/articles/s41... #microbiology #survivalstrategies #motilitymatters

First gen proud! Nice to see an analysis from the chemistry PoV

Charlie Hind@hindcharlie.bsky.social

New study from the Women in Supramolecular Chemistry (WISC) revealing the unique challenges resulting from being First Gen (first generation of a family to access Higher Education) in science and showing how these persist at every stage of a career in academia: pubs.rsc.org/en/content/a...