Brian Carrick

Brian Carrick

@bcarrick.bsky.social

Shurl and Kay Curci Fellow of the Life Sciences Research Foundation | Postdoc scientist with Lori Passmore at the MRC LMB | Biochemistry PhD with Judith Kimble and Marvin Wickens | Lover of all things RNA.

1.2K followers366 following15 posts

Brian Carrick
@bcarrick.bsky.social

Congrats to all the winners - and a special shout out to my PhD mentor, Judith Kimble, for receiving the Thomas Hunt Morgan Medal for lifetime achievement in genetics!!

Genetics Society of America@genetics-gsa.bsky.social

🏫 Elizabeth W. Jones Award for Excellence in Education: Brian Donovan 🎓 GSA Early Career Medal: @mexpositoalonso.bsky.social, @ucberkeleyofficial.bsky.social 🌎 Thomas Hunt Morgan Medal: Judith Kimble, @uwbiochem.bsky.social 🔬 George W. Beadle Award: Aaron Mitchell, @universityofga.bsky.social 2/3🧵

Brian Carrick
@bcarrick.bsky.social

The latest from our group (@lapassmore.bsky.social)! Congrats to James and the rest of the authors! Phosphorylation-dependent tuning of mRNA deadenylation rates www.nature.com/articles/s41...

nature.comPhosphorylation-dependent tuning of mRNA deadenylation rates - Nature Structural & Molecular BiologyStowell et al. show that the intrinsically disordered region (IDR) of Puf3 binds the Ccr4–Not deadenylase complex using an extended interface. Phosphorylation of the IDR regulates the interaction to t...
Brian Carrick
@bcarrick.bsky.social

I'm very excited that I have been elected as a Research Fellow at Clare Hall, University of Cambridge (@clarehallcambridge.bsky.social). It's a pleasure to join such a great community! www.clarehall.cam.ac.uk/directory/br...

clarehall.cam.ac.ukBrian Carrick - Clare HallDr Brian Carrick Dr Brian Carrick is a postdoctoral researcher at the MRC Laboratory of Molecular Biology (LMB) in the group of Dr Lori Passmore, where he studies how messenger RNAs (mRNAs) are regula...

Brian Carrick reposted

Lori Passmore
@lapassmore.bsky.social

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

MRC Laboratory of Molecular Biology@mrclmb.ac.uk

We’re looking for a #postdoc to join Lori Passmore’s group, within a programme aimed at understanding addition of mRNA poly(A) tails More info: www.nature.com/naturecareer... Closes 06 OCT #ScienceJobs #PostdocJobs

Brian Carrick reposted

Chris Lapointe
@lapointelab.bsky.social

A fun collaboration with @rasilab.bsky.social led by Rachael Bakker. We used an RNA base editor to analyze at scale how substitutions within an RNA or RNA-binding protein affect binding. doi.org/10.1101/2025...

Subramaniam Lab@rasilab.bsky.social

Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social! We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo. www.biorxiv.org/content/10.1...

biorxiv.orgDeaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactionsProtein-RNA interactions govern nearly every aspect of RNA metabolism and are frequently dysregulated in disease. While individual protein residues and RNA nucleotides critical for these interactions ...
Brian Carrick
@bcarrick.bsky.social

Happy to see this work published in RNA, and thanks to the editors for the interview/Meet the First Author Feature! Surprisingly, we found that mutating an RNA binding protein's ability to bind RNA did not remove all biological function. #RNAsky #RNAbiology. rnajournal.cshlp.org/content/31/5...

rnajournal.cshlp.orgThe PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNA A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
Brian Carrick
@bcarrick.bsky.social

It was great working with Chen Qiu, Traci Hall, and all the other authors on this project! Using a combination of structural, biophysical, and in vivo stem cell analyses, we investigated how an RBP and a partner regulate adjacent binding elements in a critical RNA. #RNAsky #RNAbiology rdcu.be/d5pER

rdcu.beA higher order PUF complex is central to regulation of C. elegans germline stem cellsNature Communications - PUF proteins, conserved stem cell regulators, maintain germline stem cells with partner proteins in nematodes. Here, authors discover a complex of two FBF-2 PUF proteins and...
Brian Carrick
@bcarrick.bsky.social

I’m excited to share this story. We found that mutating an RNA binding protein’s ability to bind RNA did not remove all biological function, but when combined with a mutation that affects protein interactions, the RBP no longer functioned. www.biorxiv.org/content/10.1...

biorxiv.orgThe PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNALike all canonical PUF proteins, C. elegans FBF-2 binds to specific RNAs via tripartite recognition motifs (TRMs). Here we report that an FBF-2 mutant protein that cannot bind to RNA, is nonetheless b...
Brian Carrick
@bcarrick.bsky.social

We also found that partnerships drive a spatially patterned switch from repression to activation of the target gld-1. Huge thanks to everyone who contributed to this work and all the members of the Kimble/Wickens groups over the years! 2/2

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