Rebecca A. Gladstone

Rebecca A. Gladstone

@becctococcus.bsky.social

Microbial population genomics | opportunistic pathogen ecology | AMR, vaccines, and prevention. I study why some bacterial lineages move from colonisation to disease. UiO. Often outdoors in Norway.

687 followers584 following13 posts

Pinned

Rebecca A. Gladstone
@becctococcus.bsky.social

EC-K-Typing v4.0.0 is out! 🧬 The E. coli group 2/3 capsule database now includes 109 K-loci (up from 90), updated phenotype assignments, curated annotations, provenance docs, and a reproducible private-DB builder. github.com/rgladstone/E...

github.comRelease EC-K-Typing database v4.0.0 · rgladstone/EC-K-typingEC-K-Typing database v4.0.0 This release expands the group 2 and group 3 reference database from 90 to 109 K-locus records. Database changes Added 16 sequence-defined loci assigned EC-K-Typing ide...
Rebecca A. Gladstone
@becctococcus.bsky.social

#ISPPD14 is "local" this time 🤩 In the spirit of Copenhagen I have set off by bike fully loaded and I am now relaxing on the ferry from Oslo🚴🏼‍♀️⛴️🚴🏼‍♀️ #ISPPD2026 Really looking forward to the conference and seeing old friends 😁 #pneumo

Rebecca A. Gladstone reposted

Alan McNally
@alanmcn1.bsky.social

Am stoked and thrilled that our latest paper is now out. A longitudinal study of invasive E. coli from children in the Netherlands over 50 years www.sciencedirect.com/science/arti...

sciencedirect.comLineage dynamics of invasive Escherichia coli isolates in the Netherlands from 1975 to 2021: a retrospective longitudinal genomic analysisEscherichia coli is a common cause of invasive infections such as bloodstream and cerebrospinal fluid infections in neonates. Strains positive for the…
View full thread
Rebecca A. Gladstone
@becctococcus.bsky.social

Capsules K1, K5, and K2 were the most common transporter-dependent K-loci across infection types and geographical locations. In Europe, K1, K5 and K2, together with K100 and K52, accounted for 58% of multidrug-resistant infections.

View full thread
Rebecca A. Gladstone
@becctococcus.bsky.social

It's still largely infeasible for national genomic surveillance at the scale AST data is available (here 24,866 BSI and 28,639 UTI E. coli, 2006–2021), but combining existing 3254 BSI genomes and AST data allowed us to estimate the importance of this notorious MDR clone in Norwegian UTIs.

Rebecca A. Gladstone reposted

Tommi Mäklin
@themaklin.bsky.social

New preprint: we looked into production of the bacterial toxin colibactin and found that MDR E. coli from the global north have co-evolved with endemic colibactin producers, acquiring colibactin resistance genes before undergoing clonal expansions. www.biorxiv.org/content/10.1...

biorxiv.orgCo-evolution between colibactin production and resistance is linked to clonal expansions in Escherichia coliSpecific strains of Escherichia coli employ the polyketide synthase island to produce a metabolite called colibactin that is implicated in colorectal tumorigenesis via its genotoxic effect on human DN...

Rebecca A. Gladstone reposted

Adrian Cazares
@cazares-adr.bsky.social

Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics We just did that to study the history of #AMR spread @science.org doi.org/10.1126/scie... If you like time travel & biology, this 🧵is for you👇

doi.orgPre- and postantibiotic epoch: The historical spread of antimicrobial resistancePlasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...

Rebecca A. Gladstone reposted

James McInerney
@jomcinerney.bsky.social

New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards. We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...

biorxiv.orgGenomic constraints shape the evolution of alternative routes to drug resistance in prokaryotesBackground Variation within the prokaryotic pangenome is not random, and natural selection that favours particular combinations of genes appears to dominate over random drift. What is less clear is wh...
Rebecca A. Gladstone
@becctococcus.bsky.social

Being able to data plasmid acquisition, and to see the diversity of plasmids being gained and lost from lineages, was really eye opening! It was a pleasure to contribute my tiny bit to this huge paper and the data has so much more to give! @arredondo.bsky.social @gerrythill.bsky.social et al.

Wellcome Sanger Institute@sangerinstitute.bsky.social

Read ‘Plasmid-driven strategies for clone success in Escherichia coli.’ From @sangerinstitute.bsky.social @uitnorgesarktiske.bsky.social, the University of Oslo, and others, in @naturecomms.bsky.social, here ⤵️ www.nature.com/articles/s41...

nature.comPlasmid-driven strategies for clone success in Escherichia coli - Nature CommunicationsPlasmids can encode multiple traits that contribute to the emergence and dissemination of their bacterial hosts. Here the authors use Nanopore long-read technology to sequence the complete genomes of ...

Rebecca A. Gladstone reposted

Andrew Page
@andrewjpage.bsky.social

I'm putting together a Microbial Bioinformatics starter pack to help get everyone connected in our community. Let me know if there are any bluesky users to be added and share so that twitter refugees can tune back in to the fantastic world microbes go.bsky.app/3ezLo7e

Rebecca A. Gladstone reposted

Andrew Page
@andrewjpage.bsky.social

We are hiring remote bioinformaticians at @theiagen . If you have a passion for microbial bioinformatics or public health, send your CV to careers@theiagen.com . You can be based nearly anywhere but need to be available to work US business hours.

Rebecca A. Gladstone reposted

Iain Johnston
@mitomaths.bsky.social

RTs much appreciated... would love to reach both AMR and biomath folks! "Evolutionary accumulation modelling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance" arxiv.org/abs/2411.00219 We think EvAM methods have some potential in AMR. 🧵

Rebecca A. Gladstone reposted

Rebecca Henderson
@rebecca-henderson.bsky.social

Interesting and useful post from Altmetric. TDLR: 🎉 BlueSky is an awesome place to share research. ❌ Don’t use link shorteners (unless it’s the DOI one) ✅ Keep the link in the post (don’t remove it once you have the auto-preview) #AcademicSky #PhDSky

Altmetric@altmetric.com

BLUESKY MEGA-THREAD Altmetric is thrilled and also LITERALLY RELIEVED to officially announce: We are now tracking research attention as it happens on Bluesky! We have been picking up posts on the site since late Oct. Our team is on Bluesky all day answering questions. Let's get into it!

Rebecca A. Gladstone reposted

Tommi Mäklin
@themaklin.bsky.social

New paper: We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers. www.sciencedirect.com/science/arti...

sciencedirect.comGeographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coliBiomedical research has implicated the bacterial metabolite colibactin as a causal risk factor for several cancer types, in particular, colorectal can…
Rebecca A. Gladstone
@becctococcus.bsky.social

How invasive are different E .coli capsules and how many are there? Find out here and use the group 2 and 3 database to type your own! medrxiv.org/cgi/content/...

medrxiv.orgGroup 2 and 3 ABC-transporter dependant capsular K-loci contribute significantly to variation in the invasive potential of Escherichia coliThe major opportunistic pathogen Escherichia coli is the largest cause of antimicrobial resistance (AMR) associated infections and deaths globally. Considerable antigenic diversity has been documented...

You are up to date.