Benoit Bruneau

Benoit Bruneau

@benoitbruneau.bsky.social

Cardiac developmental biologist. Oakland and San Francisco. Hi friends! 🇨🇦

5.9K followers2K following2.8K posts

Benoit Bruneau reposted

Ale Mongera
@mongeralab.bsky.social

Our review on the interplay between metabolism and tissue mechanics is now published in @dev-journal.bsky.social Development!

International Society of Developmental Biology@isdb.bsky.social

Metabolism is traditionally studied at the individual cell level, yet its role during development is very much under-appreciated. @mongeralab.bsky.social, @matyasbl.bsky.social and Olivier Pourquié lab discuss this interesting interplay between metabolism and morphogenesis: doi.org/10.1242/dev....

Benoit Bruneau
@benoitbruneau.bsky.social

Good proof of concept result in preclinical models but tragic outcome in human for first DMD gene therapy trial. This won’t fly. www.cell.com/cell/abstrac...

cell.comIn vivo genome-editing therapy for Duchenne muscular dystrophy: Preclinical studies and first-in-human trialA single-dose AAV-CRISPR therapy restores dystrophin in humanized DMD mice and achieves durable editing with manageable safety in non-human primates. In a first-in-human DMD trial, the therapy yields ...

Benoit Bruneau reposted

Darío Lupiáñez
@dariloops.bsky.social

Replying to @dariloops.bsky.social

12/15 These findings, alongside other results, are available in our preprint! Check it out! 🧵👇 www.biorxiv.org/content/10.6...

biorxiv.orgEvolution of CTCF underlies the establishment of loop extrusion as a predominant chromatin folding mechanism in vertebratesCTCF is a DNA-binding protein that emerged in the last bilaterian ancestor and that plays a central role in 3D genome organization. Yet, despite its relevance, genomic studies have revealed notable di...
Benoit Bruneau
@benoitbruneau.bsky.social

I am here for this

The New York Times@nytimes.com

“Nothing bad happens in the puppy box.” More than a million people have watched “Puppy Live,” a round-the-clock livestream of newborn puppies in Finland. The cameras will roll until the pups go to their permanent homes in December. nyti.ms/4zgQxZB

Benoit Bruneau reposted

Rita Strack
@ritastrack.bsky.social

Replying to @michaelhendricks.bsky.social

The fact that AI is not your peer and is therefore fundamentally unqualified to do peer review is a hill I will die on.

Benoit Bruneau reposted

The Guardian
@theguardian.com

‘Pure arrogance’: anger in Finland as Google illegally fells 250,000 trees for datacentre

theguardian.com‘Pure arrogance’: anger in Finland as Google illegally fells 250,000 trees for datacentreCompany ordered to stop work at two sites in country, which has found itself at forefront of tech firms’ latest push Behind a wire fence lies a vast gaping wound of earth. Before Google’s arrival a few months ago, an estimated quarter of a million trees occupied the 330 hectares (815 acres) of forest near the town of Muhos in rural northern Finland. Now they are all gone. After the tech company illegally stripped the entire area to build a datacentre – taking even the top soil with it – all that remains is a vast expanse of mud indented with the trail marks of machinery, puddles and mounds of earth, roots and branches. Residents say that brown water flowing off the site is going into a stream that feeds the Oulujoki River. Continue reading...

Benoit Bruneau reposted

Surprised Eel Historian, PhD
@greenleejw.bsky.social

Have you ever gotten in a fight w/ a neighbor? Was it about eels? In 1277, a Wiltshire man named William Durdi charged 3 of his neighbors w/ poaching eels from him. Sadly for William, a jury dismissed the case, finding the men had taken the eels from their own fishing spots. 🗃️🧪

Benoit Bruneau reposted

Drew Friedmann
@drewfriedmann.bsky.social

An old friend asked if I had any videos of cilia laying around for her class to see. I dug up this one from about 10 years ago and it could maybe win a prize for 'most similar to a wacky waving inflatable tube man'.

Benoit Bruneau reposted

Aaron Cohen
@unlikelywords.bsky.social

Put 110% into 100% of things you do and you might be surprised at the results and what you can achieve. It’s about maximum effort every single moment of every single day.

Benoit Bruneau
@benoitbruneau.bsky.social

This is so cool! Can’t wait to see Idefix’s photos

Astronomer Royal for Scotland | Catherine Heymans@astroroyalscot.bsky.social

And Lift Off! A glorious launch of #MMX, the start of an amazingly awesome 5 yr round trip to Mars' moon Phobos. 1yr to get there, 3yrs exploration landing on the surface (twice), then 1yr to get home with the bounty (2tbls of Phobos dust), arriving in the Australian outback in 2031! 🥳🔭🧪🛰️🚀

Benoit Bruneau reposted

Daniel Jost - Physical Biology of Chromatin group
@djost-physbiol.bsky.social

🚨 New preprint from the lab. SMC-mediated loop extrusion organizes the 3D genome. But how does this process—well characterized in vitro on naked DNA—navigate the crowded, nucleosome-dense chromatin landscape? Check the tweetorial below ⬇️ www.biorxiv.org/content/10.6...

biorxiv.orgUnderstanding the role of chromatin accessibility and compaction on loop extrusion dynamicsLoop extrusion by SMC complexes is a fundamental mechanism regulating the three-dimensional genome organization, but how these molecular motors navigate through the crowded, nucleosome-covered chromat...

Benoit Bruneau reposted

Di Jiang
@dijiang319.bsky.social

Last week @science.org A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis | Science www.science.org/doi/10.1126/...

science.orgA DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesisMammalian biology unfolds over time, within tissues and organs opaque to our eyes and instruments. We applied DNA Typewriter, a sequential molecular recorder, to record the cell lineage of a mouse ove...

Benoit Bruneau reposted

Gladstone Institutes
@gladstoneinst.bsky.social

There isn't another organization quite like Gladstone. In this video, President Deepak Srivastava shares what makes us different.

youtube.comThis Is Gladstone | Message from Gladstone President Deepak SrivastavaThere isn't another organization quite like Gladstone. In this video, President Deepak Srivastava shares what makes us different. We're focused on changing the future of medicine to one where we don't just manage disease, we cure it, and even prevent i...

Benoit Bruneau reposted

The Washington Post
@washingtonpost.com

Virginia high school students wanted to help their peers identify speedy and safe walking routes to school. They developed SafeWalkr, which combines data from Google Maps and street databases to map crosswalks, traffic and sidewalk coverage.

washingtonpost.comStudents created a program to make walking safer — and schools are now using itThree Northern Virginia high school seniors decided that because most map programs are for drivers, they would make one for pedestrians.

Benoit Bruneau reposted

Tom Freeman
@tomfreeman.bsky.social

The Very Hungry Games, an epic four-movie saga of one caterpillar's struggle first to survive and then to overthrow a tyranny (part III, set during the chrysalis phase, will be told largely in flashback but also cover the adventures of an earthworm ally)

Stephen Bush@stephenkb.bsky.social

Either this show will be a massive failure, which will have big commercial consequences and therefore terrible creative ones elsewhere in HBO/Skydance, or it will be a success, which will result in new frontiers of padding across every other established property.

Benoit Bruneau reposted

Mir Lab
@mirlab.bsky.social

1/ Our paper, “Enhancer binding kinetics explain transcription factor hub formation,” is now published! Here we set out to understand why transcription factors form bright clusters or “hubs” in the nucleus, and whether those hubs actually control gene activity. tinyurl.com/38uf8348

tinyurl.comEnhancer binding kinetics explain transcription factor hub formationTranscription factors (TFs) form dynamic, high-concentration clusters, condensates, or hubs, proposed to increase TF binding frequency at target enhancers. However, how enhancer sequence shapes hub pr...

Benoit Bruneau reposted

Alejandro Montenegro
@aemonten.bsky.social

Editors and reviewers, just like authors, are quite busy and are trying their best. Being rude with us editors helps no one. Being understanding, on the other hand, goes a long way. Thank you for your patience.

Benoit Bruneau reposted

Gladstone Institutes
@gladstoneinst.bsky.social

Seth Shipman (@seth-shipman.bsky.social) )has been recognized for pioneering molecular technologies that record cellular activity, expand genome editing, and target antibiotic-resistant superbugs. @calacademy.bsky.social

gladstone.orgGladstone’s Seth Shipman Named Fellow of the California Academy of Sciences | Gladstone InstitutesShipman is recognized for pioneering molecular technologies that record cellular activity, expand genome editing, and target antibiotic-resistant superbugs.
Benoit Bruneau
@benoitbruneau.bsky.social

why is it that France has never over the past 60 years produced a good or popular rock group/singer? (Plastic Bertrand doesn't count he was a proto-Milli Vanilli and the real guy is Belgian)