Benoît Zuber

Benoît Zuber

@benoitzuber.bsky.social

Professor at University of Bern, Switzerland. Structural Biology, Neuroscience, and Toxins. #TeamTomo #CryoEM #DubochetCenterForImaging

88 followers86 following12 posts

Benoît Zuber
@benoitzuber.bsky.social

DCI–Bern Practical Workshop on CEMOVIS 2026 — registration open. Hands-on workshop on Cryo-Electron Microscopy of Vitreous Sections (HPF → cryo-sectioning → cryo-TEM), Institute of Anatomy, University of Bern, with MIC & DCI-Bern. 🧵👇

Benoît Zuber
@benoitzuber.bsky.social

Using cryo-EM, we solved the NetF pre-pore, pore, and co-structure with ANTXR2. Although NetF and anthrax PA share the same receptor, their binding modes differ completely: NetF engages ANTXR2 laterally across vWA and Ig-like domains, while PA targets the apical MIDAS motif.

Benoît Zuber
@benoitzuber.bsky.social

This lateral engagement positions NetF close to the membrane, enabling direct lipid contacts and pore insertion, possibly a conserved strategy among clostridial hemolysin β-PFTs. With Chang Wang, Filippo Cattalani, Ioan Iacovache (@coldpopeye.bsky.social), Horst Posthaus, and colleagues.

Benoît Zuber
@benoitzuber.bsky.social

Paper alert🚨 Label your protein of interest and localize it in cryoET 👁️❄️ Genetically encoded FerriTag as a specific label for cryo-electron tomography: Structure www.cell.com/structure/fu...

cell.comGenetically encoded FerriTag as a specific label for cryo-electron tomographyWang et al. present an optimized labeling strategy for cryo-electron tomography based on genetically encoded FerriTag. This system uses rapamycin to recruit iron-loaded ferritin to target proteins, en...

Benoît Zuber reposted

Marc Bühler
@marcbuhler.bsky.social

We are hiring-join us!

FMI science@fmiscience.bsky.social

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

Benoît Zuber
@benoitzuber.bsky.social

Out now at IUCJ doi.org/10.1107/S205...

doi.orgIn situ high-resolution cryo-EM reconstructions from CEMOVISVitreous sectioning (CEMOVIS) is an alternative to FIB milling for generating thin samples suitable for cryo-EM imaging. We show that CEMOVIS samples preserve the high-resolution structural details of...
Benoît Zuber@benoitzuber.bsky.social

Happy to announce our latest preprint. High resolution ribosomes in cells obtained on CEMOVIS (frozen-hydrated sections) www.biorxiv.org/content/10.1... in collaboration with @grigoriefflab.bsky.social and Wanda Kukulski.

Benoît Zuber reposted

fotiadislab.bsky.social
@fotiadislab.bsky.social

Please check out our latest cryo-EM structure in the Journal of Structural Biology X: Structure of the PTS glucose transporter IICB stalled in an intermediate conformation. www.sciencedirect.com/science/arti... Congratulations Patrick for this great work !

sciencedirect.comCryo-EM structure of a phosphotransferase system glucose transporter stalled in an intermediate conformationThe phosphotransferase system glucose-specific transporter IICBGlc serves as a central nutrient uptake system in bacteria. It transports glucose acros…

Benoît Zuber reposted

Sjors Scheres
@sjorsscheres.bsky.social

Come and set up your own group at the @mrclmb.bsky.social in Cambridge, UK. Feel free to chat/email me with questions.

MRC Laboratory of Molecular Biology@mrclmb.ac.uk

Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology! You will be supported by core funding, excellent facilities & enthusiastic colleagues. Apply by 18 MAR www.nature.com/naturecareer...

Benoît Zuber
@benoitzuber.bsky.social

Our latest JACS paper: high-resolution cryoEM of #aerolysin in lipid environment shows pore properties and 4 key constriction rings for #nanopore sensing. Collaboration with #DalPeraro & #Cao labs. @coldpopeye.bsky.social @unibern.bsky.social #EPFL #UNIGE #DubochetCenter #MIC shorturl.at/qyzbb

shorturl.atAerolysin Nanopore Structures Revealed at High Resolution in a Lipid EnvironmentAerolysin is a β-pore-forming toxin produced by most Aeromonas bacteria, which has attracted large attention in the field of nanopore sensing due to its narrow and charged pore lumen. Structurally sim...

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