Bertoglio lab (FMC/UFSC)

journals.sagepub.comSage Journals: Discover world-class researchSubscription and open access journals from Sage, the world's leading independent academic publisher.

3 Aug

🐭 Excited to share our latest review on psychedelic effects on fear extinction @isabel-werle.bsky.social journals.sagepub.com/doi/10.1177/...

pnas.orgmechanoLight: A genetically encoded fluorescent biosensor for visualizing 5-HT2AR mechanotransduction in live cells | PNASG protein–coupled receptors (GPCRs) are pivotal sensors of the mechanical environment, yet how they sense and transduce physical stimuli into bioch...

mechanoLight: A genetically encoded fluorescent biosensor for visualizing 5-HT2AR mechanotransduction in live cells www.pnas.org/doi/abs/10.1...

doi.orgSage Journals: Discover world-class researchSubscription and open access journals from Sage, the world's leading independent academic publisher.

Psychedelics and psychosis: A systematic review of recent-era studies (1984-2025) doi.org/10.1177/0269...

nature.comThe intermediate hippocampus integrates shock-observation and spatial information during observational fear memory in male rats - Nature CommunicationsThe authors find that in rats, responses to witnessing others’ distress scale with hippocampal place-field firing, linking observed danger to the observer’s location. Associated spatial maps are stabi...

The intermediate hippocampus integrates shock-observation and spatial information during observational fear memory in male rats www.nature.com/articles/s41...

nature.comNeurobehavioral changes in fear generalization in clinical high risk for psychosis - Translational PsychiatryTranslational Psychiatry - Neurobehavioral changes in fear generalization in clinical high risk for psychosis

Neurobehavioral changes in fear generalization in clinical high risk for psychosis www.nature.com/articles/s41...

nature.comCircuit mechanisms for disentangled representations and generalization in the hippocampus - Nature NeuroscienceThe hippocampus encodes different aspects of experience as disentangled variables, enabling flexible recombination and generalization to new situations. This code is supported by the geometry of popul...

Circuit mechanisms for disentangled representations and generalization in the hippocampus www.nature.com/articles/s41...

nature.comStimulus-specific recruitment of human amygdala neurons predicts episodic memory encoding success - Nature NeuroscienceThe study shows that stimulus-specific neurons in the human amygdala determine which experiences become lasting memory, revealing a mechanism that predicts episodic memory formation and may guide futu...

Stimulus-specific recruitment of human amygdala neurons predicts episodic memory encoding success www.nature.com/articles/s41...

nature.comInterneurons and network activity in the cerebral cortex: a developmental dialogue - Nature Reviews NeuroscienceNeuronal activity is traditionally viewed as instructing cortical interneuron development. In this Review, Moissidis and Marín discuss how interneurons also actively shape early postnatal network acti...

Interneurons and network activity in the cerebral cortex: a developmental dialogue www.nature.com/articles/s41...

onlinelibrary.wiley.comQuantitative Assessment of Mesoscale Cellular Order and Organization in the Mouse HippocampusThe hippocampus is characterized by a stereotypical macroscopic structure, where the nuclei are densely and heterogeneously packed among different subregions of the hippocampus. Despite the fact that...

Quantitative Assessment of Mesoscale Cellular Order and Organization in the Mouse Hippocampus onlinelibrary.wiley.com/doi/10.1002/...

link.springer.comSex-related differences in outcomes following psilocybin or escitalopram: a Bayesian secondary analysis - PsychopharmacologyRationale Major depressive disorder (MDD) shows marked sex differences in prevalence, symptomatology, and treatment response. However, females remain underrepresented in many clinical trials, and sex-...

Sex-related differences in outcomes following psilocybin or escitalopram: a Bayesian secondary analysis link.springer.com/article/10.1...

nature.comWhy pharma firms are betting billions on psychedelic drugs despite setbacksRegulatory pushback stalled the field. But researchers are optimistic about mind-altering drugs as potential treatments for depression and mood disorders.

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Why pharma firms are betting billions on psychedelic drugs despite setbacks www.nature.com/articles/d41...

doi.orgSingle Intranasal Administration of the Psychedelic Mebufotenin for Treatment-Resistant DepressionThis randomized trial assesses the effect of single doses of intranasal mebufotenin benzoate on depression symptoms among adults with treatment-resistant depression.

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Single Intranasal Administration of the Psychedelic Mebufotenin for Treatment-Resistant Depression: A Randomized Clinical Trial doi.org/10.1001/jama...

pubs.acs.org/jmcmar/artic...

pubs.acs.orgExploring a Druggable Hydrophobic Tunnel in the 5-HT2A Receptor with Potent PhenethylaminesAbstract. The serotonin 2A receptor is the most abundant excitatory serotonin receptor in the brain and the target for serotonergic psychedelics. Despite i

www.nature.com/articles/s41...

nature.comSustained antidepressant-like effects of psychedelics through 5-HT2AR–β-arrestin signaling - Nature NeuroscienceThis study shows that the sustained antidepressant-like effect of psychedelics is driven by 5-HT2A receptor–β-arrestin signaling. Repeated low-dose LSD preserves this effect in mice without inducing h...

osf.ioGradual Extinction via US Intensity Reduction: a Translational Test of Fear Memory Updating in HumansRelapse of fear-related symptoms after exposure-based treatment remains a major challenge across anxiety disorders. One potential explanation is that extinction learning yields a new memory trace rath...

Gradual Extinction via US Intensity Reduction: a Translational Test of Fear Memory Updating in Humans osf.io/preprints/ps...

doi.orgMechanistic Evaluation of Psilocybin in Neurodegenerative Disorders: Relevance of 5-HT2A Receptors and Downstream PathwaysMore than fifty million individuals worldwide are experiencing neurodegenerative disorders, which include Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease,...

Mechanistic Evaluation of Psilocybin in Neurodegenerative Disorders: Relevance of 5-HT2A Receptors and Downstream Pathways doi.org/10.2174/0118...

doi.orgSage Journals: Discover world-class researchSubscription and open access journals from Sage, the world's leading independent academic publisher.

Dorsal Raphe Revisited: A Systems Neuroscience Lens on Psychedelic Drug Action doi.org/10.1177/2831...

doi.orgPsychedelics and Reward Processing: Before and After the 1970 Controlled Substances Act - Matthew C. Company, Dylan J. Lifshitz, M. Farris Sawaya, Kevin S. Murnane, 2026This narrative review traces how the scientific understanding of psychedelics has intersected with “reward processing” from before the Controlled Substances Act...

Psychedelics and Reward Processing: Before and After the 1970 Controlled Substances Act doi.org/10.1177/2831...

doi.orgFrontiers | 5-HT2A receptor activation induces CB1-dependent presynaptic inhibitory long-term depression in the nucleus accumbens coreThe serotonin 2A receptor (5-HT2A) is a Gq/11-coupled receptor implicated in reward processing, neuropsychiatric disorders, and the actions of serotonergic p...

5-HT2A receptor activation induces CB1-dependent presynaptic inhibitory long-term depression in the nucleus accumbens core doi.org/10.3389/fpha...

link.springer.comA preliminary pharmacodynamic overview of objective measures of intoxication in regular and fast-acting cannabis edibles - PsychopharmacologyRationale Existing research on biological markers of intoxication while under the influence of cannabis is expansive. We aimed to characterize these parameters across different commercially available ...

A preliminary pharmacodynamic overview of objective measures of intoxication in regular and fast-acting cannabis edibles link.springer.com/article/10.1...

A cell death ballet in two acts www.science.org/doi/10.1126/...

science.orgscience.org

nature.comThe anatomy of a personal health agent - NatureA multi-agent framework that coordinates data science, medical reasoning and health coaching over longitudinal wearable and clinical data to provide holistic personal health support is described.

The anatomy of a personal health agent www.nature.com/articles/s41...

nature.comFunctional architecture of the human insula - NatureA functional architecture of the human insula links cytoarchitecture to directed and asymmetric electrophysiological interactions, with mechanistic implications for cognitive modulation of pain and in...

Functional architecture of the human insula www.nature.com/articles/s41...

elifesciences.orgComplementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discriminationStable and dynamic prelimbic neurons preserve threat-generalization gradients despite ensemble turnover, supporting enduring representations of stimulus significance rather than freezing.

Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination elifesciences.org/articles/111...

Nanodispersible CBD for generalized anxiety disorder: Comparative emerging clinical evidence with first-line anxiolytics and mechanistic insights from network pharmacology and pharmacogenomics doi.org/10.1016/j.aj...

doi.orgClinical Evidence on Psilocybin and Its Representation in Media ReportingThis systematic review assesses annual counts of clinical trials of therapeutic psilocybin use and contemporaneous media articles published from 2014 to 2025 and examines whether media coverage aligne...

Clinical Evidence on Psilocybin and Its Representation in Media Reporting: A Systematic Review doi.org/10.1001/jama...

nature.comCortex-wide imaging in naturally behaving mice with 1-gram wireless mesoscopes - NatureNature - Cortex-wide imaging in naturally behaving mice with 1-gram wireless mesoscopes

Cortex-wide imaging in naturally behaving mice with 1-gram wireless mesoscopes www.nature.com/articles/s41...

nature.comTwo distinct projection pathways converge onto the same BLA neurons to contribute to fear memory retrieval - Molecular PsychiatryMolecular Psychiatry - Two distinct projection pathways converge onto the same BLA neurons to contribute to fear memory retrieval

Two distinct projection pathways converge onto the same BLA neurons to contribute to fear memory retrieval www.nature.com/articles/s41...

nature.comA prefrontal–bed nucleus pathway controls aversive memory specificity independently of glucocorticoids - Nature CommunicationsOvergeneralizing aversive memories to safe contexts is a feature of stress-related disorders. Here, authors show that a prefrontal–bed nucleus pathway controls the specificity of aversive memories ind...

A prefrontal–bed nucleus pathway controls aversive memory specificity independently of glucocorticoids www.nature.com/articles/s41...

nature.comSpatiotemporal remodeling in habenula marks the onset of depression-related phenotypes - Nature NeuroscienceMolina et al. show in chronically stressed mice that neuronal and transcriptional adaptations in the habenula coincide with the onset of depressive phenotype, guiding temporally defined antidepressant...

Spatiotemporal remodeling in habenula marks the onset of depression-related phenotypes www.nature.com/articles/s41...

sciencedirect.comsciencedirect.com

Impact of previous acute and chronic stress on negative glucocorticoid feedback in laboratory animal: theoretical background and methodological concerns www.sciencedirect.com/science/arti...

doi.orgFrontiers | Caution before canonisation: a clinical and implementation science perspective on psychedelicsRecent advances in psychedelic research have renewed interest in the potential therapeutic role of psychedelic-assisted interventions in psychiatry. Early cl...

Caution before canonisation: a clinical and implementation science perspective on psychedelics doi.org/10.3389/fpsy...

www.cell.com/current-biol...

cell.comKetamine attenuates habenula activity in response to aversive outcomes during Pavlovian learningTranslating a preclinical model to humans using 7-tesla MRI, Pulcu et al. show that ketamine reduces habenula activity for the expectation of aversive outcomes during Pavlovian learning. This provides...

pubs.acs.orgGi Signaling Does Not Differentiate Hallucinogenic from Nonhallucinogenic 5-HT2A Receptor AgonistsAbstract. A recent publication by Xu et al. suggests that Gi activation following 5-HT2AR stimulation differentiates hallucinogenic from nonhallucinogenic

Gi Signaling Does Not Differentiate Hallucinogenic from Nonhallucinogenic 5-HT2A Receptor Agonists pubs.acs.org/acncdm/artic...

nature.comKetamine induces synaptic and monoaminergic remodeling in human iPSC-derived neurons - Translational PsychiatryTranslational Psychiatry - Ketamine induces synaptic and monoaminergic remodeling in human iPSC-derived neurons

Ketamine induces synaptic and monoaminergic remodeling in human iPSC-derived neurons www.nature.com/articles/s41...

sciencedirect.comSubanesthetic ketamine modulates region-specific neural and endocrine responses to acute stress in ratsExposure to acute, inescapable stress triggers a coordinated neural and endocrine response across corticolimbic and brainstem circuits. Although suban…

Subanesthetic ketamine modulates region-specific neural and endocrine responses to acute stress in rats www.sciencedirect.com/science/arti...

doi.orgInvestigation of the pharmacological and circuit basis for psychedelic drug effects on interval timing in mice - PsychopharmacologyRationale Classical psychedelic drugs such as the tryptamine psilocybin can alter temporal perception. Previously, the phenylethylamine psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI), a 5-HT2A rece...

Investigation of the pharmacological and circuit basis for psychedelic drug effects on interval timing in mice doi.org/10.1007/s002...

Ketamine administration reduced conditioned defensive behaviour and upregulated protein expression associated with neuroplasticity in a planarian model of aversive memory reactivation doi.org/10.1016/j.pn...

Stage- and context-dependent modulation of fear memory by oxytocin: neurobiological mechanisms and implications for PTSD doi.org/10.1016/j.ne...

Cannabidiol attenuates behavioral impairments and deficits in parvalbumin interneurons and their perineuronal nets induced by adolescent stress in adult mice doi.org/10.1016/j.pn...

doi.orgBeyond psychedelic exceptionalism: how people combine meditation with psychoactive substances, and how this relates to well-being - PsychopharmacologyBackground Combining meditation with psychoactive substances is often assumed to be a niche practice centred on classic psychedelics. We sought to broaden this narrative in two cross-sectional studies...

Beyond psychedelic exceptionalism: how people combine meditation with psychoactive substances, and how this relates to well-being doi.org/10.1007/s002...

doi.orgWhat goes up must comedown: prevalence rates, characteristics, and coping strategies concerning MDMA aftereffects - PsychopharmacologyRationale MDMA is increasingly being studied for therapeutic applications, yet the prevalence and characteristics of post-acute negative effects remain debated. Objectives We aimed to characterize MDM...

What goes up must comedown: prevalence rates, characteristics, and coping strategies concerning MDMA after effects doi.org/10.1007/s002...

doi.orgSerotonin 1B receptors expressed on forebrain excitatory neurons mediate the post-acute anxiolytic response to psilocybin in mice - PsychopharmacologyIntroduction Psilocybin can produce rapid and sustained antidepressant-like and anxiolytic effects, yet the receptor and circuit mechanisms underlying these behavioral changes remain unclear. While th...

5-HT1B receptors expressed on forebrain excitatory neurons mediate the post-acute anxiolytic response to psilocybin in mice doi.org/10.1007/s002...

nature.comThe endocannabinoid system and the ageing brain - Nature Reviews NeuroscienceAge-related changes in endocannabinoid system (ECS) activity might contribute to the decline in cognitive function observed during ageing. In this review, Andreas Zimmer discusses how evidence from ge...

The endocannabinoid system and the ageing brain www.nature.com/articles/s41...

nature.comAn aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience - Nature NeuroscienceThis study identifies a secreted phospholipase in the hippocampal dentate gyrus that mediates an aging-sensitive compensatory mechanism promoting cognitive resilience and neuroprotection.

An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience www.nature.com/articles/s41...

5-HT2A receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin www.nature.com/articles/s41...

nature.comnature.com

science.orgCan predictive tools tell us who really needs antidepressants?Amid a U.S. push for “deprescribing,” researchers are finding new ways to match patients to their optimal treatment

Can predictive tools tell us who really needs antidepressants? www.science.org/content/arti...

Medical cannabis for the treatment of insomnia doi.org/10.1002/1465...

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cell.comResilience and vulnerability in the midbrain dopamine system during agingThe midbrain dopamine system is integral to movement, reward, and motivation, and its dysfunction underlies a range of brain disorders. Age is a primary risk factor for many of these disorders, yet sy...

Resilience and vulnerability in the midbrain dopamine system during aging www.cell.com/trends/neuro...

doi.orgFrontiers | Protective effects of cannabidiol against acute stress: behavioral responses and corticosterone concentrations in female Wistar ratsBackgroundCannabidiol (CBD) has been widely investigated for its potential anxiolytic and stress-modulating effects. This study evaluated whether CBD reduces...

Protective effects of cannabidiol against acute stress: behavioral responses and corticosterone concentrations in female Wistar rats doi.org/10.3389/fpha...